Document Detail

Current understanding of mitochondrial DNA in breast cancer.
MedLine Citation:
PMID:  19624415     Owner:  NLM     Status:  MEDLINE    
The recent surge in mitochondrial research has been driven by the identification of mitochondria-associated diseases and the role of mitochondria in apoptosis and aging. Mitochondrial DNA (mtDNA) has been proposed to be involved in carcinogenesis because of its high susceptibility to mutations and limited repair mechanisms in comparison to nuclear DNA. As mtDNA lacks introns, it has been suggested that most mutations will occur in coding sequences. The subsequent accumulation of mutations may lead to tumor formation. By virtue of their clonal nature, high copy number and high frequent mutations may provide a powerful molecular biomarker for the detection of cancer. It has been suggested that the extent of mtDNA mutations might be useful in the prognosis of cancer outcome and/or the response to certain therapies. In this review article, we aim to provide a brief summary of our current understanding of mitochondrial genetics and biology, review the mtDNA alterations reported in breast cancer, and offer some perspectives as to the emergence of mtDNA mutations, including their functional consequences in cancer development, diagnostic criteria, and therapeutic implications.
Ramin Radpour; Alex XiuCheng Fan; Corina Kohler; Wolfgang Holzgreve; Xiao Yan Zhong
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-07-13
Journal Detail:
Title:  The breast journal     Volume:  15     ISSN:  1524-4741     ISO Abbreviation:  Breast J     Publication Date:    2009 Sep-Oct
Date Detail:
Created Date:  2009-08-27     Completed Date:  2010-01-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9505539     Medline TA:  Breast J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  505-9     Citation Subset:  IM    
Laboratory for Prenatal Medicine and Gynecology Oncology, Women's Hospital/Department of Biomedicine, University of Basel, Basel CH 4031, Switzerland.
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MeSH Terms
Breast Neoplasms / genetics*
Colonic Neoplasms / genetics
Cytochromes b / genetics
DNA, Mitochondrial / genetics*
DNA, Neoplasm / genetics
Electron Transport Complex IV / genetics
Genetic Markers / genetics
Kidney Neoplasms / genetics
Mitochondrial Proton-Translocating ATPases / genetics
Oxidative Phosphorylation Coupling Factors / genetics
Stomach Neoplasms / genetics
Tumor Markers, Biological / genetics
Reg. No./Substance:
0/DNA, Mitochondrial; 0/DNA, Neoplasm; 0/Genetic Markers; 0/Oxidative Phosphorylation Coupling Factors; 0/Tumor Markers, Biological; 9035-37-4/Cytochromes b; EC Transport Complex IV; EC 3.6.1.-/F(6) ATPase; EC 3.6.3.-/Mitochondrial Proton-Translocating ATPases

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