| Current understanding of insulin resistance in hepatitis C. | |
| | |
MedLine Citation:
|
PMID: 21780897 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Important breakthroughs have been made in recent years into understanding the close interaction between hepatitis C virus (HCV) infection and glucose homeostasis. Both cross-sectional and longitudinal studies have demonstrated that infection with HCV is associated with an increased risk of developing insulin resistance and Type 2 diabetes. A direct effect of HCV on hepatocyte insulin signaling has been shown in experimental models. Some preliminary observations seem to suggest that indirect mechanisms involving extrahepatic organs might also play a role. The interaction between HCV and glucose metabolism has significant clinical consequences. Insulin resistance and Type 2 diabetes not only accelerate the histological and clinical progression of chronic hepatitis C, but also reduce the virological response to IFN-α-based therapy. Thus, understanding the mechanisms underlying HCV-associated glucose metabolism derangements is of paramount interest in order to improve the clinical management of chronic hepatitis C. This article will focus on the studies that consistently argue in favor of an interrelation between HCV and insulin resistance and will highlight the latest discoveries in this field. |
| | |
Authors:
|
Vincent Kaddai; Francesco Negro |
Related Documents
:
|
19011317 - Hemoglobin a1c: past, present and future. 20799587 - Hyperglycaemia, hypertension and their risk factors among palestine refugees served by ... 12590017 - Childhood diabetes identified in mass urine screening program in taiwan, 1993-1999. 17007657 - Diabetes retinopathy screening: audit of equity in participation and selected outcomes ... 15353407 - Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients ... 11293007 - Diabetes prevalence and risk factors in polycystic ovary syndrome. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Expert review of gastroenterology & hepatology Volume: 5 ISSN: 1747-4132 ISO Abbreviation: Expert Rev Gastroenterol Hepatol Publication Date: 2011 Aug |
Date Detail:
|
Created Date: 2011-07-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101278199 Medline TA: Expert Rev Gastroenterol Hepatol Country: England |
Other Details:
|
Languages: eng Pagination: 503-16 Citation Subset: IM |
Affiliation:
|
Department of Pathology and Immunology, Centre Médical Universitaire, Rue Michel-Servet 1, 1205 Geneva, Switzerland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Regulatory T cells in gastrointestinal tumors.
Next Document: Mycophenolate mofetil as a rescue therapy for autoimmune hepatitis patients who are not responsive t...