Document Detail


Current understanding of immunity to Trypanosoma cruzi infection and pathogenesis of Chagas disease.
MedLine Citation:
PMID:  23076807     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chagas disease caused by Trypanosoma cruzi remains an important neglected tropical disease and a cause of significant morbidity and mortality. No longer confined to endemic areas of Latin America, it is now found in non-endemic areas due to immigration. The parasite may persist in any tissue, but in recent years, there has been increased recognition of adipose tissue both as an early target of infection and a reservoir of chronic infection. The major complications of this disease are cardiomyopathy and megasyndromes involving the gastrointestinal tract. The pathogenesis of Chagas disease is complex and multifactorial involving many interactive pathways. The significance of innate immunity, including the contributions of cytokines, chemokines, reactive oxygen species, and oxidative stress, has been emphasized. The role of the components of the eicosanoid pathway such as thromboxane A(2) and the lipoxins has been demonstrated to have profound effects as both pro- and anti-inflammatory factors. Additionally, we discuss the vasoconstrictive actions of thromboxane A(2) and endothelin-1 in Chagas disease. Human immunity to T. cruzi infection and its role in pathogen control and disease progression have not been fully investigated. However, recently, it was demonstrated that a reduction in the anti-inflammatory cytokine IL-10 was associated with clinically significant chronic chagasic cardiomyopathy.
Authors:
Fabiana S Machado; Walderez O Dutra; Lisia Esper; Kenneth J Gollob; Mauro M Teixeira; Stephen M Factor; Louis M Weiss; Fnu Nagajyothi; Herbert B Tanowitz; Nisha J Garg
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-10-18
Journal Detail:
Title:  Seminars in immunopathology     Volume:  34     ISSN:  1863-2300     ISO Abbreviation:  Semin Immunopathol     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-15     Completed Date:  2013-04-12     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  101308769     Medline TA:  Semin Immunopathol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  753-70     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adaptive Immunity
Animals
Chagas Disease / epidemiology,  immunology*,  pathology
Humans
Immunity, Innate
Life Cycle Stages
Trypanosoma cruzi / growth & development,  immunology*
Grant Support
ID/Acronym/Agency:
AI054578/AI/NIAID NIH HHS; AI06538/AI/NIAID NIH HHS; AI076248/AI/NIAID NIH HHS; HL088230/HL/NHLBI NIH HHS; HL094802/HL/NHLBI NIH HHS; HL73732/HL/NHLBI NIH HHS; R01 AI054578/AI/NIAID NIH HHS; R01 AI076248/AI/NIAID NIH HHS; R21 AI068538/AI/NIAID NIH HHS; T32 AI070117/AI/NIAID NIH HHS
Comments/Corrections

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