Document Detail


Current understanding of the genetic basis of psoriasis.
MedLine Citation:
PMID:  20477039     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Psoriasis is a common, immunologically mediated, inflammatory and hyperproliferative disease of the skin and joints, with a multifactorial genetic basis. Recently, the association of psoriasis with loci at HLA-Cw*0602, IL12B, IL23A, IL23R, TNFAIP3, TNIP1, ZNF313 and IL4/IL13, and copy number variations in the beta-defensin and late-cornified envelope (LCE) gene loci were described. Here, we discuss the advances in the technology that has lead to the identification of these genes and their presumed role in the pathogenesis of psoriasis. Although it is now generally accepted that psoriatic lesions are caused by abnormal reactivity of specific T cells in the skin, these findings suggest that alterations in the epidermal barrier, innate defenses and processing of inflammatory signals may all contribute to the triggering of nonspecific innate immune mechanisms, which, in combination with altered IL-23 signaling, may lead to the dysregulation of T-cell-driven immune responses.
Authors:
Johann E Gudjonsson; Andrew Johnston
Related Documents :
8125129 - T cell clones from psoriasis skin lesions can promote keratinocyte proliferation in vit...
24618889 - Epigenetic silencing of apoptosis-inducing gene expression can be efficiently overcome ...
20642779 - A novel mechanism of cutaneous photo-aging mediated by the impairment of lymphatic func...
15148489 - Significance of selectively targeted apoptotic rete cells in graft-versus-host disease.
11093609 - Characteristics of the inflammatory process around skin-penetrating titanium implants f...
20090949 - Therapeutic efficacy and immunological response of ccl5 antagonists in models of contac...
9234749 - Characterization of human t- and b-cell epitopes in the c terminus of plasmodium falcip...
9384589 - Defective b cell receptor-mediated responses in mice lacking the ets protein, spi-b.
24068329 - Peroxisome proliferator-activated receptor-α activation protects against endoplasmic re...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Expert review of clinical immunology     Volume:  5     ISSN:  1744-8409     ISO Abbreviation:  Expert Rev Clin Immunol     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2010-05-18     Completed Date:  2010-06-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101271248     Medline TA:  Expert Rev Clin Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  433-43     Citation Subset:  -    
Affiliation:
Department of Dermatology, University of Michigan, Room 6427, Medical Science Building I, 1301 Catherine, Ann Arbor, MI, USA. johanng@med.umich.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Paradoxical adverse effects of anti-TNF-alpha treatment: onset or exacerbation of cutaneous disorder...
Next Document:  New insights into the pathogenesis and treatment of Takayasu arteritis.