Document Detail

Current trends and progress in clinical applications of oocyte cryopreservation.
MedLine Citation:
PMID:  23562954     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: To delineate the current trends in the clinical application of oocyte cryopreservation.
RECENT FINDINGS: Although the first live birth from oocyte cryopreservation was reported approximately three decades ago, significant improvement in the clinical application of oocyte cryopreservation took place only over the past decade. On the basis of the available evidence suggesting that success rates with donor oocyte vitrification are similar to that of IVF with fresh donor oocytes, the American Society of Reproductive Medicine has recently stated that oocyte cryopreservation should no longer be considered experimental for medical indications, outlying elective oocyte cryopreservation. Meanwhile, a few surveys on the attitudes toward oocyte cryopreservation revealed that elective use for the postponement of fertility is currently the most common indication for oocyte cryopreservation. Most recently, a randomized controlled trial revealed important evidence on the safety of nondonor oocyte cryopreservation, and confirmed that the clinical success of vitrification is comparable to that of IVF with fresh oocytes.
SUMMARY: The evidence suggesting similar IVF success rates with both donor and nondonor cryopreserved oocytes compared with fresh oocytes will increase the utilization of elective oocyte cryopreservation. Appropriate counseling of women for oocyte cryopreservation requires the establishment of age-based clinical success rates with cryopreserved oocytes for various indications.
Aylin P Cil; Emre Seli
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Current opinion in obstetrics & gynecology     Volume:  25     ISSN:  1473-656X     ISO Abbreviation:  Curr. Opin. Obstet. Gynecol.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-02     Completed Date:  2013-12-10     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  9007264     Medline TA:  Curr Opin Obstet Gynecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  247-54     Citation Subset:  IM    
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MeSH Terms
Age Factors
Cryopreservation / methods,  trends*
Fertilization in Vitro / methods,  trends*
Infertility / epidemiology,  therapy*
Pregnancy Rate
Randomized Controlled Trials as Topic
United States / epidemiology
Grant Support

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