Document Detail

Current trends in narcotic use in pregnancy and neonatal outcomes.
MedLine Citation:
PMID:  21376165     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: The purpose of this study was to evaluate trends and prevalence of chronic prescription narcotic use during pregnancy and the subsequent neonatal outcomes.
STUDY DESIGN: We conducted a retrospective cohort study of all deliveries at Mayo Clinic from 1998 through 2009; the data was obtained from prospectively maintained obstetrics and neonatal databases.
RESULTS: Over the study time period, there were 26,314 deliveries; 167 women used prescription narcotics chronically during pregnancy. The prevalence of women who used chronic narcotics during their pregnancy increased over the time period from 1998-2009 (P < .0001). Neonatal withdrawal syndrome occurred in 10 of neonates (5.6%), and all but 1 of these neonates required pharmacologic treatment for the disease.
CONCLUSION: Chronic narcotic use during pregnancy is increasing in prevalence. Neonatal withdrawal syndrome occurred in 5.6% of the exposed neonates. Although neonatal withdrawal syndrome is uncommon, it is clinically significant. Physicians need to consider the risks and benefits carefully when prescribing narcotic pain medications during pregnancy.
Ann Kellogg; Carl H Rose; Roger H Harms; William J Watson
Related Documents :
21498005 - Leptin withdrawal after birth: a neglected factor account for cognitive deficit in offs...
434195 - Progesterone secretion and fetal development during prolonged starvation in the pig.
6626645 - Changes in noradrenergic vesicle markers of rabbit oviducts during progesterone treatment.
21145845 - High viral load and deregulation of the progesterone receptor signaling pathway: associ...
18286825 - Transposition of great arteries in an infant born after prenatal diagnosis of trisomy 2...
25020915 - 2.2 abnormal cerebroplacental ratio predicts adverse outcomes in dichorionic twins.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  204     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  259.e1-4     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2011 Mosby, Inc. All rights reserved.
Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Protein kinase C?2 inhibition reduces hyperglycemia-induced neural tube defects through suppression ...
Next Document:  Being too large for gestational age precedes childhood obesity in African Americans.