| Current trends in lactate metabolism: introduction. | |
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MedLine Citation:
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PMID: 18379209 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In September 2006, at the Integrative Physiology of Exercise meeting in Indianapolis, IN, a symposium entitled "Current Trends in Lactate Metabolism" was presented. This short paper introduces two papers from that symposium. The first paper by L. Bruce Gladden briefly summarizes key pieces of evidence that support the cell-to-cell lactate shuttle, a concept that is no longer an hypothesis but that, instead, is now an established theory that provides the context for discussions of whole body metabolism. Gladden also offers a critical appraisal of the intracellular lactate shuttle and evaluates an ongoing controversy relative to the role of lactate in acid-base balance. In the second paper, Hashimoto and Brooks provide their evidence in support of the intracellular lactate shuttle and a lactate oxidation complex in the inner mitochondrial membrane. They also postulate that lactate is a cell-signaling molecule, "lactormone," that can upregulate gene and protein expression. Both papers have been updated since their original presentations and represent the current state of knowledge. |
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Authors:
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L Bruce Gladden |
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Publication Detail:
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Type: Introductory Journal Article |
Journal Detail:
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Title: Medicine and science in sports and exercise Volume: 40 ISSN: 0195-9131 ISO Abbreviation: Med Sci Sports Exerc Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-04-01 Completed Date: 2008-05-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8005433 Medline TA: Med Sci Sports Exerc Country: United States |
Other Details:
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Languages: eng Pagination: 475-6 Citation Subset: IM; S |
Affiliation:
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Department of Kinesiology, Auburn University, Auburn, AL 36849-5323, USA. gladdlb@auburn.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acid-Base Equilibrium Humans Lactic Acid / metabolism* Muscle, Skeletal / metabolism United States |
| Chemical | |
Reg. No./Substance:
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50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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