Document Detail

Current treatment recommendations for leishmaniasis.
MedLine Citation:
PMID:  1477452     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To review the epidemiology, clinical presentation, risk factors for transmission, and pathogenesis of leishmaniasis, as well as current treatment options for this disease. DATA SOURCES/DATA SELECTION: We reviewed unclassified medical-threat briefing material, subject-matter reviews, and case reports from the world's infectious disease literature. We concentrated on literature pertaining to the pathogenesis and management of leishmaniasis indigenous to Southwest Asia. DATA EXTRACTION: Data from subject reviews published in the English language were evaluated. Case reports and clinical trials provided supplemental data on evolving theories and management options. DATA SYNTHESIS: The clinical presentation of leishmaniasis is highly variable. Management relies heavily upon the use of parenteral antimonial drugs. Although these agents are effective in most cases, toxicity and the emergence of resistance limit the usefulness of standard therapies. Alternative treatment modalities include heat, surgical curettage, ketoconazole, metronidazole, pentamidine, rifampin, amphotericin B, aminoglycosides, allopurinol, and immunotherapy. CONCLUSIONS: Although the number of reported cases of leishmaniasis in the US has generally been low, there is a possibility that more cases may be reported in the future because of the large number of military personnel returning to this country from endemic areas. Medical personnel, particularly those working in governmental institutions, should be familiar with the pathogenesis of this unusual infection as well as potential treatment options.
J T Moss; J P Wilson
Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  The Annals of pharmacotherapy     Volume:  26     ISSN:  1060-0280     ISO Abbreviation:  Ann Pharmacother     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1993-02-05     Completed Date:  1993-02-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9203131     Medline TA:  Ann Pharmacother     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1452-5     Citation Subset:  IM    
Pharmacy Branch, Academy of Health Sciences, Ft. Sam Houston, TX.
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MeSH Terms
Antiprotozoal Agents / therapeutic use
Leishmaniasis* / drug therapy,  epidemiology,  parasitology
Leishmaniasis, Cutaneous / drug therapy,  epidemiology,  parasitology
Leishmaniasis, Visceral / drug therapy,  epidemiology,  parasitology
Risk Factors
Species Specificity
Reg. No./Substance:
0/Antiprotozoal Agents
Comment In:
Ann Pharmacother. 1993 Oct;27(10):1286   [PMID:  8251704 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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