Document Detail


Current total parenteral nutrition solutions for the neonate are inadequate.
MedLine Citation:
PMID:  10929677     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The amino acid requirements of the parenterally fed neonate are poorly defined. Newborn infants are at risk for amino acid deficiency and toxicity, due to lack of small intestinal metabolism and metabolic immaturity. We discuss recent evidence that identifies inadequacies of commercial amino acid solutions with respect to the balance and quantity of aromatic amino acids, and sulphur amino acids. We present data demonstrating that impaired small intestinal metabolism (or lack of first pass metabolism) alters the whole body requirement for methionine, threonine, and arginine, and discuss the potential adverse effects of excess or inadequate parenteral amino acid intake.
Authors:
J A Brunton; R O Ball; P B Pencharz
Related Documents :
21822447 - Acid peptic diseases: pharmacological approach to treatment.
6725467 - Identification of amino acid phenylthiohydantoins by multicomponent analysis of ultravi...
15853887 - Evidence of selection for low cognate amino acid bias in amino acid biosynthetic enzymes.
19946157 - Bias-dependent amino-acid-induced conductance changes in short semi-metallic carbon nan...
1503387 - The effect of metal chelators on lipid peroxidation in stored erythrocytes.
11361077 - Gluconobacter oxydans: its biotechnological applications.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in clinical nutrition and metabolic care     Volume:  3     ISSN:  1363-1950     ISO Abbreviation:  Curr Opin Clin Nutr Metab Care     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-11-08     Completed Date:  2000-11-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9804399     Medline TA:  Curr Opin Clin Nutr Metab Care     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  299-304     Citation Subset:  IM    
Affiliation:
Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amino Acids / administration & dosage,  metabolism
Cysteine / metabolism
Humans
Infant Nutritional Physiological Phenomena*
Infant, Newborn
Intestine, Small / metabolism
Methionine / metabolism
Nutritional Requirements
Parenteral Nutrition, Total*
Phenylalanine / metabolism
Solutions*
Tyrosine / metabolism
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Solutions; 52-90-4/Cysteine; 55520-40-6/Tyrosine; 63-68-3/Methionine; 63-91-2/Phenylalanine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cystic fibrosis: nutritional status and micronutrients.
Next Document:  Are oral nutritional supplements of benefit to patients in the community? Findings from a systematic...