| Current total parenteral nutrition solutions for the neonate are inadequate. | |
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MedLine Citation:
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PMID: 10929677 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The amino acid requirements of the parenterally fed neonate are poorly defined. Newborn infants are at risk for amino acid deficiency and toxicity, due to lack of small intestinal metabolism and metabolic immaturity. We discuss recent evidence that identifies inadequacies of commercial amino acid solutions with respect to the balance and quantity of aromatic amino acids, and sulphur amino acids. We present data demonstrating that impaired small intestinal metabolism (or lack of first pass metabolism) alters the whole body requirement for methionine, threonine, and arginine, and discuss the potential adverse effects of excess or inadequate parenteral amino acid intake. |
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Authors:
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J A Brunton; R O Ball; P B Pencharz |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current opinion in clinical nutrition and metabolic care Volume: 3 ISSN: 1363-1950 ISO Abbreviation: Curr Opin Clin Nutr Metab Care Publication Date: 2000 Jul |
Date Detail:
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Created Date: 2000-11-08 Completed Date: 2000-11-16 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9804399 Medline TA: Curr Opin Clin Nutr Metab Care Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 299-304 Citation Subset: IM |
Affiliation:
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Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
/
administration & dosage,
metabolism Cysteine / metabolism Humans Infant Nutritional Physiological Phenomena* Infant, Newborn Intestine, Small / metabolism Methionine / metabolism Nutritional Requirements Parenteral Nutrition, Total* Phenylalanine / metabolism Solutions* Tyrosine / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Solutions; 52-90-4/Cysteine; 55520-40-6/Tyrosine; 63-68-3/Methionine; 63-91-2/Phenylalanine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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