Document Detail

Current total parenteral nutrition solutions for the neonate are inadequate.
MedLine Citation:
PMID:  10929677     Owner:  NLM     Status:  MEDLINE    
The amino acid requirements of the parenterally fed neonate are poorly defined. Newborn infants are at risk for amino acid deficiency and toxicity, due to lack of small intestinal metabolism and metabolic immaturity. We discuss recent evidence that identifies inadequacies of commercial amino acid solutions with respect to the balance and quantity of aromatic amino acids, and sulphur amino acids. We present data demonstrating that impaired small intestinal metabolism (or lack of first pass metabolism) alters the whole body requirement for methionine, threonine, and arginine, and discuss the potential adverse effects of excess or inadequate parenteral amino acid intake.
J A Brunton; R O Ball; P B Pencharz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in clinical nutrition and metabolic care     Volume:  3     ISSN:  1363-1950     ISO Abbreviation:  Curr Opin Clin Nutr Metab Care     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-11-08     Completed Date:  2000-11-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9804399     Medline TA:  Curr Opin Clin Nutr Metab Care     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  299-304     Citation Subset:  IM    
Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Canada.
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MeSH Terms
Amino Acids / administration & dosage,  metabolism
Cysteine / metabolism
Infant Nutritional Physiological Phenomena*
Infant, Newborn
Intestine, Small / metabolism
Methionine / metabolism
Nutritional Requirements
Parenteral Nutrition, Total*
Phenylalanine / metabolism
Tyrosine / metabolism
Reg. No./Substance:
0/Amino Acids; 0/Solutions; 52-90-4/Cysteine; 55520-40-6/Tyrosine; 63-68-3/Methionine; 63-91-2/Phenylalanine

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