Document Detail


Current thought regarding the mechanism of action of negative pressure wound therapy with reticulated open cell foam.
MedLine Citation:
PMID:  19034159     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There are currently 2 main theories regarding the mechanism of action of negative pressure wound therapy with reticulated open cell foam (NPWT/ROCF) as delivered by V.A.C.(R) Therapy (KCI, San Antonio, TX). The first is based on the stimulatory effect of microstrain on cellular mitogenesis, angiogenesis, and elaboration of growth factors. This is the same mechanism that is operational in controlled Ilizarovian distraction or in tissue expansion. The second is based on the enhancement of the dynamics of microcirculation by active evacuation of excess interstitial fluid in the form of edema. Physiologically, there is a lowering of the heightened capillary afterload and a qualitative dilution of contained microcontaminants, bacteria, and proinflammatory cytokines. Based on these effects, the use of NPWT/ROCF has found a place in the management of high-energy traumatic wounds and certain high-risk elective surgical wounds.
Authors:
Lawrence X Webb; Hans-Christoph Pape
Related Documents :
19365019 - In vitro sealing of clear corneal cataract incisions with a novel biodendrimer adhesive.
12355219 - Anastomotic healing in the rat colon: comparison between a radiological method, breakin...
9423719 - Effect of pulsatile pressure on the breaking strength and movement of prolene sutures.
8878199 - Effect of scleral buckling on unsutured cataract wound strength.
1953849 - Advantages of handsewn over stapled bowel anastomosis.
24576919 - Lower eyelid tension in young adults determined by a simple lid tensiometer.
12358329 - Physiological responses to the 6-min walk test in patients with chronic obstructive pul...
1885229 - Postexercise hypotension is not sustained in normal and hypertensive humans.
20581399 - Forearm and upper-arm oscillometric blood pressure comparison in acutely ill adults.
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of orthopaedic trauma     Volume:  22     ISSN:  1531-2291     ISO Abbreviation:  J Orthop Trauma     Publication Date:    2008 Nov-Dec
Date Detail:
Created Date:  2008-11-26     Completed Date:  2009-03-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807705     Medline TA:  J Orthop Trauma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S135-7     Citation Subset:  IM    
Affiliation:
Department of Orthopaedic Surgery, Wake Forest University School of Medicine, Winston-Salem, NC, USA. lxwebb@wfubmc.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Mechanotransduction, Cellular*
Microcirculation
Models, Biological
Negative-Pressure Wound Therapy / instrumentation*,  methods*
Neovascularization, Physiologic*
Wound Healing / physiology*
Wounds, Penetrating / physiopathology*,  therapy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  History of open wound and fracture treatment.
Next Document:  The role of negative pressure wound therapy with reticulated open cell foam in the treatment of war ...