Document Detail

Current thought regarding the mechanism of action of negative pressure wound therapy with reticulated open cell foam.
MedLine Citation:
PMID:  19034159     Owner:  NLM     Status:  MEDLINE    
There are currently 2 main theories regarding the mechanism of action of negative pressure wound therapy with reticulated open cell foam (NPWT/ROCF) as delivered by V.A.C.(R) Therapy (KCI, San Antonio, TX). The first is based on the stimulatory effect of microstrain on cellular mitogenesis, angiogenesis, and elaboration of growth factors. This is the same mechanism that is operational in controlled Ilizarovian distraction or in tissue expansion. The second is based on the enhancement of the dynamics of microcirculation by active evacuation of excess interstitial fluid in the form of edema. Physiologically, there is a lowering of the heightened capillary afterload and a qualitative dilution of contained microcontaminants, bacteria, and proinflammatory cytokines. Based on these effects, the use of NPWT/ROCF has found a place in the management of high-energy traumatic wounds and certain high-risk elective surgical wounds.
Lawrence X Webb; Hans-Christoph Pape
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of orthopaedic trauma     Volume:  22     ISSN:  1531-2291     ISO Abbreviation:  J Orthop Trauma     Publication Date:    2008 Nov-Dec
Date Detail:
Created Date:  2008-11-26     Completed Date:  2009-03-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807705     Medline TA:  J Orthop Trauma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S135-7     Citation Subset:  IM    
Department of Orthopaedic Surgery, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
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MeSH Terms
Mechanotransduction, Cellular*
Models, Biological
Negative-Pressure Wound Therapy / instrumentation*,  methods*
Neovascularization, Physiologic*
Wound Healing / physiology*
Wounds, Penetrating / physiopathology*,  therapy*

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