Document Detail

Current strategies used to enhance the paracellular transport of therapeutic polypeptides across the intestinal epithelium.
MedLine Citation:
PMID:  15814245     Owner:  NLM     Status:  MEDLINE    
The intent of this paper is to update the reader on various strategies which have been utilized to increase the paracellular permeability of protein and polypeptide drugs across the intestinal epithelium. Structural features of protein and polypeptide drugs, together with the natural anatomical and physiological features of the gastrointestinal (GI) tract, have made oral delivery of this class of compounds extremely challenging. Interest in the paracellular route for the transport of therapeutic proteins and polypeptides following oral administration has recently intensified and continues to be explored. The assumption that molecules with a large molecular weight are not able to diffuse through the tight junctions of the intestinal membrane has been challenged by current research, along with an increased understanding of tight junction physiology.
Nazila Salamat-Miller; Thomas P Johnston
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  International journal of pharmaceutics     Volume:  294     ISSN:  0378-5173     ISO Abbreviation:  Int J Pharm     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-07     Completed Date:  2005-08-18     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7804127     Medline TA:  Int J Pharm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  201-16     Citation Subset:  IM    
Division of Pharmaceutical Sciences, Room 211A, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO 64110-2499, USA.
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MeSH Terms
Biological Transport / physiology*
Intestinal Absorption / drug effects,  physiology*
Intestinal Mucosa / drug effects,  metabolism*
Peptides / pharmacokinetics*,  therapeutic use*
Tight Junctions / drug effects,  metabolism
Reg. No./Substance:

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