| Current strategies to minimize hepatic ischemia-reperfusion injury by targeting reactive oxygen species. | |
| | |
MedLine Citation:
|
PMID: 22459037 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Ischemia-reperfusion is a major component of injury in vascular occlusion both during liver surgery and during liver transplantation. The pathophysiology of hepatic ischemia-reperfusion includes a number of mechanisms including oxidant stress that contribute to various degrees to the overall organ damage. A large volume of recent research has focused on the use of antioxidants to ameliorate this injury, although results in experimental models have not translated well to the clinic. This review focuses on critical sources and mediators of oxidative stress during hepatic ischemia-reperfusion, the status of current antioxidant interventions, and emerging mechanisms of protection by preconditioning. While recent advances in regulation of antioxidant systems by Nrf2 provide interesting new potential therapeutic targets, an increased focus must be placed on more in-depth mechanistic investigations in hepatic ischemia-reperfusion injury and translational research in order to refine current strategies in disease management. |
| | |
Authors:
|
Hartmut Jaeschke; Benjamin L Woolbright |
Related Documents
:
|
3153667 - On the trichromatic and opponent-process theories: an article by e. schrödinger. 22453077 - Fire (facilitating implementation of research evidence): a study protocol. 22394977 - The use of ruminants for biomedical research in perinatalogy. 22565587 - Educational advantage. 12178947 - Residency patterns and secondary migration of refugees. 3153667 - On the trichromatic and opponent-process theories: an article by e. schrödinger. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
|
Title: Transplantation reviews (Orlando, Fla.) Volume: 26 ISSN: 1557-9816 ISO Abbreviation: Transplant Rev (Orlando) Publication Date: 2012 Apr |
Date Detail:
|
Created Date: 2012-03-30 Completed Date: 2012-08-06 Revised Date: 2013-04-03 |
Medline Journal Info:
|
Nlm Unique ID: 8804364 Medline TA: Transplant Rev (Orlando) Country: United States |
Other Details:
|
Languages: eng Pagination: 103-14 Citation Subset: IM |
Copyright Information:
|
Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA. hjaeschke@kumc.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antioxidants
/
therapeutic use* Apoptosis Glutathione / therapeutic use Heat-Shock Proteins / therapeutic use Humans Ischemic Preconditioning Kupffer Cells / metabolism Lipid Peroxidation Liver / blood supply* Mitochondria, Liver / metabolism Neutrophils / metabolism Oxidative Stress Reactive Oxygen Species / metabolism* Reperfusion Injury / metabolism, physiopathology, prevention & control* Superoxide Dismutase / therapeutic use |
| Grant Support | |
ID/Acronym/Agency:
|
P20 RR016475/RR/NCRR NIH HHS; P20 RR021940/RR/NCRR NIH HHS; P20 RR021940-06/RR/NCRR NIH HHS; R01 AA012916-10/AA/NIAAA NIH HHS; R01 AA12916/AA/NIAAA NIH HHS; R01 DK070195/DK/NIDDK NIH HHS; R01 DK070195-05/DK/NIDDK NIH HHS; T32 ES007079-26A2/ES/NIEHS NIH HHS; T32 ES007079-32/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Antioxidants; 0/Heat-Shock Proteins; 0/Reactive Oxygen Species; 70-18-8/Glutathione; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of brain death on organ quality and transplant outcome.
Next Document: The role of normothermic extracorporeal perfusion in minimizing ischemia reperfusion injury.