Document Detail

Current strategies for ischemic stroke prevention: role of multimodal combination therapies.
MedLine Citation:
PMID:  17934879     Owner:  NLM     Status:  MEDLINE    
Stroke remains a global leading cause of death and long-term disability, highlighting the need for more effective treatment approaches. The majority of strokes are of ischemic origin, often caused by large- or small-artery atherothrombosis, or cardioembolism. Considering the systemic nature of the atherothrombotic disease process, stroke patients are at increased risk for ischemic events in several vascular territories: cerebral, coronary and peripheral. Due to the limited options for acute stroke therapies, stroke prevention is an important therapeutic approach. In addition to the management of modifiable risk factors such as hypertension, dyslipidemia and smoking through pharmacotherapy or lifestyle adjustments, anticoagulants, surgical and perhaps endovascular approaches are indicated in certain patients. Antiplatelet therapies using various agents are a cornerstone of secondary stroke prevention. To ensure the appropriate continuum of care after hospitalization for ischemic stroke, some interventions for the prevention of recurrent ischemic stroke should be initiated during the acute hospitalization setting and maintained in the out-patient setting.
M J Alberts; B Ovbiagele
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2007-10-15
Journal Detail:
Title:  Journal of neurology     Volume:  254     ISSN:  0340-5354     ISO Abbreviation:  J. Neurol.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-25     Completed Date:  2008-02-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1414-26     Citation Subset:  IM    
Dept. of Neurology, Northwestern University, Feinberg School of Medicine, 710 North Lake Shore Drive, Room 1420, Chicago, IL 60611, USA.
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MeSH Terms
Antihypertensive Agents
Combined Modality Therapy*
Fibrinolytic Agents
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Ischemia / complications
Risk Factors
Stroke / etiology,  prevention & control*
Tissue Plasminogen Activator
Reg. No./Substance:
0/Antihypertensive Agents; 0/Fibrinolytic Agents; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; EC Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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