| Current status and recent advances of liver transplantation from donation after cardiac death. | |
| | |
MedLine Citation:
|
PMID: 22180833 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
The last decade saw increased organ donation activity from donors after cardiac death (DCD). This contributed to a significant proportion of transplant activity. Despite certain drawbacks, liver transplantation from DCD donors continues to supplement the donor pool on the backdrop of a severe organ shortage. Understanding the pathophysiology has provided the basis for modulation of DCD organs that has been proven to be effective outside liver transplantation but remains experimental in liver transplantation models. Research continues on how best to further increase the utility of DCD grafts. Most of the work has been carried out exploring the use of organ preservation using machine assisted perfusion. Both ex-situ and in-situ organ perfusion systems are tested in the liver transplantation setting with promising results. Additional techniques involved pharmacological manipulation of the donor, graft and the recipient. Ethical barriers and end-of-life care pathways are obstacles to widespread clinical application of some of the recent advances to practice. It is likely that some of the DCD offers are in fact probably "prematurely" offered without ideal donor management or even prior to brain death being established. The absolute benefits of DCD exist only if this form of donation supplements the existing deceased donor pool; hence, it is worthwhile revisiting organ donation process enabling us to identify counter remedial measures. |
| | |
Authors:
|
M Thamara Pr Perera; Simon R Bramhall |
Related Documents
:
|
15080453 - Renal dysplasia and urinary tract infection in a bull mastiff puppy. 12944193 - Urodynamics prior to renal transplantation--its impact on treatment decision and final ... 22130283 - Validation of the chronic kidney disease epidemiology collaboration (ckd-epi) equation ... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: World journal of gastrointestinal surgery Volume: 3 ISSN: 1948-9366 ISO Abbreviation: World J Gastrointest Surg Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-12-19 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101532473 Medline TA: World J Gastrointest Surg Country: China |
Other Details:
|
Languages: eng Pagination: 167-76 Citation Subset: - |
Affiliation:
|
M Thamara PR Perera, Simon R Bramhall, The Liver Unit, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, United Kingdom. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: CDX2 as a marker for intestinal differentiation: Its utility and limitations.
Next Document: Laparoscopic total colectomy: Does the indication influence the outcome?