| Current status of granulocyte transfusions to treat neonatal sepsis. | |
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MedLine Citation:
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PMID: 2674109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neonates are unusually susceptible to severe bacterial infections. Antibiotic therapy has been supplemented with granulocyte transfusions (GTX) to treat neonatal infections. The precise role of GTX to treat neonatal sepsis is controversial, and 11 reports (including six controlled studies) were critically analyzed. When all data are combined, 79% of 78 neonates receiving antibiotics plus GTX survived vs. 62% of 90 infants treated only with antibiotics. Among the six controlled trials, four found significantly better survival for neonates given GTX plus antibiotics. However, each of these trials can be criticized (few subjects, heterogeneous patients, defective design, inadequate granulocyte product, etc.). Although firm recommendations for GTX cannot be made currently, it seems reasonable to combine them with antibiotics to treat septic neonates that exhibit neutropenia for age and evidence of a diminished neutrophil marrow storage pool. Once the decision to transfuse is made, neonates should receive a minimum dose of 1 x 10(9) fresh neutrophils per kg per transfusion. |
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Authors:
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R G Strauss |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Journal of clinical apheresis Volume: 5 ISSN: 0733-2459 ISO Abbreviation: J Clin Apher Publication Date: 1989 |
Date Detail:
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Created Date: 1989-10-19 Completed Date: 1989-10-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8216305 Medline TA: J Clin Apher Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 25-9 Citation Subset: IM |
Affiliation:
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Department of Pathology and Pediatrics, University of Iowa College of Medicine, Elmer L. DeGowin Memorial Blood Center, University of Iowa Hospitals and Clinics, Iowa City 52242. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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therapeutic use Bacterial Infections / complications, therapy* Blood Transfusion* Combined Modality Therapy Granulocytes / transplantation* Humans Infant, Newborn Neutropenia / complications, therapy |
| Grant Support | |
ID/Acronym/Agency:
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K04 HD00255/HD/NICHD NIH HHS; K07 HL01426/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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