Document Detail


Current status of granulocyte transfusions to treat neonatal sepsis.
MedLine Citation:
PMID:  2674109     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neonates are unusually susceptible to severe bacterial infections. Antibiotic therapy has been supplemented with granulocyte transfusions (GTX) to treat neonatal infections. The precise role of GTX to treat neonatal sepsis is controversial, and 11 reports (including six controlled studies) were critically analyzed. When all data are combined, 79% of 78 neonates receiving antibiotics plus GTX survived vs. 62% of 90 infants treated only with antibiotics. Among the six controlled trials, four found significantly better survival for neonates given GTX plus antibiotics. However, each of these trials can be criticized (few subjects, heterogeneous patients, defective design, inadequate granulocyte product, etc.). Although firm recommendations for GTX cannot be made currently, it seems reasonable to combine them with antibiotics to treat septic neonates that exhibit neutropenia for age and evidence of a diminished neutrophil marrow storage pool. Once the decision to transfuse is made, neonates should receive a minimum dose of 1 x 10(9) fresh neutrophils per kg per transfusion.
Authors:
R G Strauss
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Journal of clinical apheresis     Volume:  5     ISSN:  0733-2459     ISO Abbreviation:  J Clin Apher     Publication Date:  1989  
Date Detail:
Created Date:  1989-10-19     Completed Date:  1989-10-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8216305     Medline TA:  J Clin Apher     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  25-9     Citation Subset:  IM    
Affiliation:
Department of Pathology and Pediatrics, University of Iowa College of Medicine, Elmer L. DeGowin Memorial Blood Center, University of Iowa Hospitals and Clinics, Iowa City 52242.
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / therapeutic use
Bacterial Infections / complications,  therapy*
Blood Transfusion*
Combined Modality Therapy
Granulocytes / transplantation*
Humans
Infant, Newborn
Neutropenia / complications,  therapy
Grant Support
ID/Acronym/Agency:
K04 HD00255/HD/NICHD NIH HHS; K07 HL01426/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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