Document Detail

Current status of digestive intolerance to food protein.
MedLine Citation:
PMID:  1447626     Owner:  NLM     Status:  MEDLINE    
Digestive intolerance to food proteins may occur in childhood as a result of a wide range of etiologic and pathophysiologic mechanisms. Cow milk protein intolerance is the most common form of food intolerance in children. Food allergy and food intolerance may be confused because both produce similar symptoms, especially in young children with clinical manifestations of food allergy localized to the gastrointestinal tract. On the other hand, food-sensitive enteropathy may be defined as the clinical food-related syndromes associated with an abnormal small intestinal mucosa. Although several foods have been reported to damage the small intestinal mucosa in infancy (soy, rice, fish, chicken meat, egg), cow milk-sensitive enteropathy is the most common cause. Whatever the mechanisms, digestive intolerance to food proteins with or without enteropathy is primarily a temporary condition of infancy, in contrast to most forms of food allergy. In children with these disorders, symptoms usually resolve by 1 to 3 years of age. The variation in prevalence rates of this disorder in different countries can be explained by different diagnostic criteria. The classic food-sensitive enteropathy syndromes with chronic diarrhea and failure to thrive in infancy have become rarer in some European countries, including Spain. Some risk factors for the development of these conditions appear to be early exposure to cow milk feedings, acute infectious diarrhea, and malnutrition. Breast-feeding appears to be at least partially protective.
I Polanco
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  121     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1992-12-24     Completed Date:  1992-12-24     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S108-10     Citation Subset:  AIM; IM    
Department of Pediatrics, La Paz Children's Hospital, Universidad Autónoma, Madrid, Spain.
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MeSH Terms
Diarrhea, Infantile / immunology*
Food Hypersensitivity / diagnosis,  immunology*
Infant Nutrition Disorders / immunology*
Infant, Newborn
Intestinal Mucosa / pathology
Milk Hypersensitivity / diagnosis,  immunology
Milk Proteins / adverse effects*
Reg. No./Substance:
0/Milk Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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