Document Detail


Current status of cellular therapy for ischemic heart disease.
MedLine Citation:
PMID:  15919259     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cellular therapy for acute myocardial infarction and ischemic cardiomyopathy has entered clinical trials across the globe. Early promising results have now provided the justification for larger randomized and blinded trials to address the efficacy of cellular therapy. A variety of fresh or cultured autologous cells have been delivered by catheter-guided endocardial, catheter-guided intracoronary, catheter-guided transvenous, and direct epicardial routes. This review will summarize the clinical data and highlight salient basic science data that support the ongoing efforts to identify the optimal cellular therapy both for acute myocardial infarction and chronic ischemic cardiomyopathy patients.
Authors:
Shafie Fazel; Gilbert H L Tang; Denis Angoulvant; Massimo Cimini; Richard D Weisel; Ren-Ke Li; Terrence M Yau
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  79     ISSN:  1552-6259     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-05-27     Completed Date:  2006-08-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  S2238-47     Citation Subset:  AIM; IM    
Affiliation:
Division of Cardiovascular Surgery, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Bone Marrow Cells
Cell Differentiation
Extracellular Matrix / metabolism
Gene Therapy*
Hematopoietic Stem Cell Mobilization
Humans
Myoblasts
Myocardial Infarction / therapy*
Myocardial Ischemia / therapy*
Neovascularization, Physiologic
Stem Cell Transplantation*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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