Document Detail

Current status of HIV infection and ocular disease.
MedLine Citation:
PMID:  23047168     Owner:  NLM     Status:  In-Data-Review    
PURPOSE OF REVIEW: In the present era of highly active antiretroviral therapy (HAART), the challenges that HIV/AIDS patients face with regard to ocular complications has changed immensely; nonetheless, significant ocular morbidity persists. We present an update on these challenges, focusing particularly on the relevant literature from the past 12-18 months.
RECENT FINDINGS: Although its incidence has decreased substantially in the HAART era, cytomegalovirus (CMV) retinitis remains an important cause of ocular morbidity and predictor of mortality. Presently, patients with less than 50 CD4 T-cells/μL have an approximately equal risk of developing this potentially blinding ocular complication compared with the pre-HAART era. Less is understood about the current epidemiological considerations of ocular syphilis and HIV; however, patients with HIV may have increased likelihood of posterior syphilitic uveitis. Regarding the neuroretinal disorder associated with HIV, new ophthalmic imaging modalities are helping to uncover potentially associated structural alterations.
SUMMARY: Future challenges in the fight against HIV/AIDS-related eye disease will involve identifying additional factors conferring increased risk of CMV retinitis, understanding the scope of ocular syphilis and other eye infections in HIV patients, and furthering our understanding of the structural changes in neuroretinal disorder as an indicator of other end-organ damage.
Nicholas J Butler; Jennifer E Thorne
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current opinion in ophthalmology     Volume:  23     ISSN:  1531-7021     ISO Abbreviation:  Curr Opin Ophthalmol     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9011108     Medline TA:  Curr Opin Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  517-22     Citation Subset:  IM    
aDivision of Ocular Immunology, Wilmer Eye Institute, Johns Hopkins University School of Medicine bCenter for Clinical Trials, Department of Epidemiology, Johns Hopkins University School of Public Health, Baltimore, Maryland, USA.
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