Document Detail


Current state of knowledge on aetiology, diagnosis, management, and therapy of peripartum cardiomyopathy: a position statement from the Heart Failure Association of the European Society of Cardiology Working Group on peripartum cardiomyopathy.
MedLine Citation:
PMID:  20675664     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Peripartum cardiomyopathy (PPCM) is a cause of pregnancy-associated heart failure. It typically develops during the last month of, and up to 6 months after, pregnancy in women without known cardiovascular disease. The present position statement offers a state-of-the-art summary of what is known about risk factors for potential pathophysiological mechanisms, clinical presentation of, and diagnosis and management of PPCM. A high index of suspicion is required for the diagnosis, as shortness of breath and ankle swelling are common in the peripartum period. Peripartum cardiomyopathy is a distinct form of cardiomyopathy, associated with a high morbidity and mortality, but also with the possibility of full recovery. Oxidative stress and the generation of a cardiotoxic subfragment of prolactin may play key roles in the pathophysiology of PPCM. In this regard, pharmacological blockade of prolactin offers the possibility of a disease-specific therapy.
Authors:
Karen Sliwa; Denise Hilfiker-Kleiner; Mark C Petrie; Alexandre Mebazaa; Burkert Pieske; Eckhart Buchmann; Vera Regitz-Zagrosek; Maria Schaufelberger; Luigi Tavazzi; Dirk J van Veldhuisen; Hugh Watkins; Ajay J Shah; Petar M Seferovic; Uri Elkayam; Sabine Pankuweit; Zoltan Papp; Frederic Mouquet; John J V McMurray
Related Documents :
8309584 - Magnetic resonance evaluation of disease activity during pregnancy in multiple sclerosis.
1168324 - Primary hyperparathyroidism during the third trimester of pregnancy.
11255814 - Spontaneous remission of cyclic neutropenia during pregnancy. a case report.
12743674 - Efficacy, safety and cost of new drugs acting on the central nervous system.
2847774 - Massive feto-maternal haemorrhage: effect of passively administered anti-d in the preve...
1453404 - Extraovular and intraovular uterine contraction monitoring. a comparison.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  European journal of heart failure : journal of the Working Group on Heart Failure of the European Society of Cardiology     Volume:  12     ISSN:  1879-0844     ISO Abbreviation:  Eur. J. Heart Fail.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100887595     Medline TA:  Eur J Heart Fail     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  767-78     Citation Subset:  IM    
Affiliation:
Hatter Cardiovascular Research Institute, University of Cape Town, Cape Town, South Africa. sliwa-hahnlek@mdh-africa.org
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Elevated pulmonary artery systolic pressure in patients with coronary artery disease and left ventri...
Next Document:  Cardiac remodelling and myocardial recovery: lost in translation?