Document Detail


Current state of endoscopic therapies in Barrett's esophagus and esophageal cancer.
MedLine Citation:
PMID:  21441773     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Barrett's esophagus (BE) is a premalignant condition that predisposes patients to esophageal adenocarcinoma. This risk increases with increasing dysplasia, especially in patients with BE and high-grade dysplasia. Radical esophagectomy had long been the only option for these patients; however, it has been associated with significant morbidity and mortality. Endoscopic therapies have been increasingly used as an alternative to radical esophagectomy given the minimally invasive nature and tolerability of the procedure relative to surgery. Currently, the most widely used endoscopic therapies include endoscopic mucosal resection, photodynamic therapy, CryoSpray ablation, and radiofrequency ablation. Retrospective and prospective studies on the use of each of these modalities in patients with nondysplastic BE, dysplastic BE, and early esophageal cancer have demonstrated their effectiveness in eradication of dysplasia with or without reversion of Barrett's epithelium to normal squamous epithelium of the esophagus. These modalities are well tolerated, safe, and have few side effects. Ultimately, more research is needed regarding their ability to fully displace surgical intervention as the gold standard, although at this point their role in poor operative candidates or patients seeking conservative approaches remains promising.
Authors:
Matthew Hudson; Cui Li Lin; Fadlallah Habr
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Hospital practice (1995)     Volume:  39     ISSN:  2154-8331     ISO Abbreviation:  Hosp Pract (1995)     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-03-28     Completed Date:  2011-06-02     Revised Date:  2013-04-10    
Medline Journal Info:
Nlm Unique ID:  101268948     Medline TA:  Hosp Pract (1995)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  170-80     Citation Subset:  AIM; IM    
Affiliation:
Department of Internal Medicine, Warren Alpert School of Medicine of Brown University, Providence, RI, USA.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / pathology,  surgery,  therapy*
Barrett Esophagus / pathology,  surgery,  therapy*
Catheter Ablation / methods
Cryotherapy / methods
Equipment Design
Esophageal Neoplasms / pathology,  surgery,  therapy*
Esophagectomy / methods
Esophagoscopy / methods*
Humans
Photochemotherapy
Precancerous Conditions / pathology,  surgery,  therapy*
Comments/Corrections
Erratum In:
Hosp Pract (Minneap). 2011 Apr;39(2):116

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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