| Current state of endoscopic therapies in Barrett's esophagus and esophageal cancer. | |
| | |
MedLine Citation:
|
PMID: 21441773 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Barrett's esophagus (BE) is a premalignant condition that predisposes patients to esophageal adenocarcinoma. This risk increases with increasing dysplasia, especially in patients with BE and high-grade dysplasia. Radical esophagectomy had long been the only option for these patients; however, it has been associated with significant morbidity and mortality. Endoscopic therapies have been increasingly used as an alternative to radical esophagectomy given the minimally invasive nature and tolerability of the procedure relative to surgery. Currently, the most widely used endoscopic therapies include endoscopic mucosal resection, photodynamic therapy, CryoSpray ablation, and radiofrequency ablation. Retrospective and prospective studies on the use of each of these modalities in patients with nondysplastic BE, dysplastic BE, and early esophageal cancer have demonstrated their effectiveness in eradication of dysplasia with or without reversion of Barrett's epithelium to normal squamous epithelium of the esophagus. These modalities are well tolerated, safe, and have few side effects. Ultimately, more research is needed regarding their ability to fully displace surgical intervention as the gold standard, although at this point their role in poor operative candidates or patients seeking conservative approaches remains promising. |
| | |
Authors:
|
Matthew Hudson; Cui Li Lin; Fadlallah Habr |
Related Documents
:
|
21165633 - Pedicle subtraction osteotomy for rigid kyphosis of the dorsolumbar spine. 9670153 - Auditing mortality from upper gastrointestinal haemorrhage: impact of a high dependency... 12841563 - Visual performance after congenital nystagmus surgery using extended hang back recessio... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Hospital practice (1995) Volume: 39 ISSN: 2154-8331 ISO Abbreviation: Hosp Pract (1995) Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-03-28 Completed Date: 2011-06-02 Revised Date: 2013-04-10 |
Medline Journal Info:
|
Nlm Unique ID: 101268948 Medline TA: Hosp Pract (1995) Country: United States |
Other Details:
|
Languages: eng Pagination: 170-80 Citation Subset: AIM; IM |
Affiliation:
|
Department of Internal Medicine, Warren Alpert School of Medicine of Brown University, Providence, RI, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenocarcinoma
/
pathology,
surgery,
therapy* Barrett Esophagus / pathology, surgery, therapy* Catheter Ablation / methods Cryotherapy / methods Equipment Design Esophageal Neoplasms / pathology, surgery, therapy* Esophagectomy / methods Esophagoscopy / methods* Humans Photochemotherapy Precancerous Conditions / pathology, surgery, therapy* |
| Comments/Corrections | |
Erratum In:
|
Hosp Pract (Minneap). 2011 Apr;39(2):116 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Rapid response team interventions for severe hyperkalemia: evaluation of a patient safety initiative...
Next Document: Mitral regurgitation: current trends in diagnosis and management.