| Current smokers develop more posterior myocardial infarctions probably due to increased tendency to thrombosis. | |
| | |
MedLine Citation:
|
PMID: 10816064 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
This investigation was carried out to determine whether smokers developed smaller infarcts as assessed by peak enzyme levels and also to what extent smoking could modify infarct localization. The study included 753 patients, of whom 351 had no history of previous coronary heart disease (CHD) (angina pectoris and/or myocardial infarction (MI)). The investigation was designed as an exposed (smoking) versus non-exposed (non-smoking) cohort study. Outcome was infarct size, posterior versus non-posterior MI and non-Q-wave versus Q-wave infarcts. In the total cohort of patients, 312 (41%) were smokers, the corresponding number in the restricted cohort of patients without a previous CHD (CHD-0-pts) was 169 (48%). Smokers were younger than non-smokers, and more of them were males. It was found that infarct size was similar in smokers and in non-smokers (crude and adjusted effects). Crude effects showed that smokers developed significantly more posterior infarcts than non-smokers; odds ratio (OR) for developing a posterior MI was 1.95 (2p < 0.001) (all patients) and 2.34 (2P < 0.001) (CHD-0-pts), respectively. After adjusting for confounders (logistic regression model), OR in the two groups was 1.24 (2p = 0.256) and 1.95 (2p = 0.01), respectively. The study shows that current smokers were younger, and indicates that in those without a previous CHD, significantly more of them developed a posterior MI. |
| | |
Authors:
|
K Landmark; M Abdelnoor |
Related Documents
:
|
18805174 - Targeted myocardial microinjections of a biocomposite material reduces infarct expansio... 991264 - The clinical and angiographic spectrum of isolated, nondominant, left circumflex corona... 18195484 - Expression of sdf-1-cxcr4 axis and an anti-remodelling effectiveness of foetal-liver st... 17067624 - Acute anterior myocardial infarction followed by acute inferoposterior myocardial infar... 3366994 - Prognostic cardiac catheterization variables in survivors of acute myocardial infarctio... 18666844 - Tailored antithrombotic therapy for acute coronary syndromes. |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Scandinavian cardiovascular journal : SCJ Volume: 34 ISSN: 1401-7431 ISO Abbreviation: Scand. Cardiovasc. J. Publication Date: 2000 |
Date Detail:
|
Created Date: 2000-07-14 Completed Date: 2000-07-14 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9708377 Medline TA: Scand Cardiovasc J Country: NORWAY |
Other Details:
|
Languages: eng Pagination: 73-8 Citation Subset: IM |
Affiliation:
|
Department of Pharmacotherapeutics, Research Forum, Ullevål University Hospital, Oslo, Norway. k.h.landmark@ioks.uio.no |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Biological Markers / blood Coronary Thrombosis / complications*, enzymology, epidemiology, etiology Creatine Kinase / blood Electrocardiography Female Humans Isoenzymes L-Lactate Dehydrogenase / blood Male Middle Aged Myocardial Infarction / enzymology, epidemiology, etiology* Odds Ratio Prevalence Prognosis Retrospective Studies Smoking / adverse effects*, blood, epidemiology Sweden / epidemiology |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/Isoenzymes; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 2.7.3.2/Creatine Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Limitation of physical activity, dyspnoea and chest pain before and two years after coronary artery ...
Next Document: Atrial septal defect in adults. Thirty-eight-year follow-up of a surgically and a conservatively man...