Document Detail


Current significance of meconium plug syndrome.
MedLine Citation:
PMID:  18485962     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The significance of meconium plug syndrome is dependent on the underlying diagnosis. The incidence of pathologic finding, particularly Hirschsprung's disease, contributing to the presence of these plugs, has been debated. However, there are little recent data in the literature. Therefore, we reviewed our experience with meconium plugs as a cause of abdominal distension to evaluate the associated conditions and incidence of Hirschsprung's disease.
METHODS: We reviewed the records of newborns with meconium plugs found in the distal colon on contrast enema from 1994 to 2007. Demographics, radiologic findings, histologic findings, operative findings, and clinical courses were reviewed.
RESULTS: During the study period, 77 patients were identified. Mean gestational age was 37.4 weeks and birth weight, 2977 g. Hirschsprung's disease was found in 10 patients (13%). One had ultrashort segment disease and another had total colonic aganglionosis. Maternal diabetes was identified in 6 patients. No patients were diagnosed with cystic fibrosis, meconium ileus, malrotation, or intestinal atresia.
CONCLUSION: Meconium plugs found on contrast enema are associated with a 13% incidence of Hirschsprung's disease in our experience. Although all patients with plugs and persistent abnormal stooling patterns should prompt a rectal biopsy and genetic probe, the incidence of Hirschsprung's and cystic fibrosis may not be as high as previously reported.
Authors:
Scott J Keckler; Shawn D St Peter; Troy L Spilde; KuoJen Tsao; Daniel J Ostlie; George W Holcomb; Charles L Snyder
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric surgery     Volume:  43     ISSN:  1531-5037     ISO Abbreviation:  J. Pediatr. Surg.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-19     Completed Date:  2008-08-26     Revised Date:  2011-09-26    
Medline Journal Info:
Nlm Unique ID:  0052631     Medline TA:  J Pediatr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  896-8     Citation Subset:  IM    
Affiliation:
Department of Surgery, The Children's Mercy Hospital, Kansas City, MO 64108, USA.
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MeSH Terms
Descriptor/Qualifier:
Comorbidity
Female
Gestational Age
Hirschsprung Disease / diagnosis,  epidemiology*,  pathology
Humans
Ileus / epidemiology
Incidence
Infant, Newborn
Infant, Newborn, Diseases / diagnosis,  epidemiology*
Intestinal Obstruction / diagnosis,  epidemiology*
Length of Stay
Male
Meconium*
Pregnancy
Pregnancy in Diabetics / epidemiology
Retrospective Studies
Syndrome
Grant Support
ID/Acronym/Agency:
KL2 RR024149-05/RR/NCRR NIH HHS
Comments/Corrections

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