Document Detail


Current self-reported symptoms of attention deficit/hyperactivity disorder are associated with total brain volume in healthy adults.
MedLine Citation:
PMID:  22348063     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Reduced total brain volume is a consistent finding in children with Attention Deficit/Hyperactivity Disorder (ADHD). In order to get a better understanding of the neurobiology of ADHD, we take the first step in studying the dimensionality of current self-reported adult ADHD symptoms, by looking at its relation with total brain volume.
METHODOLOGY/PRINCIPAL FINDINGS: In a sample of 652 highly educated adults, the association between total brain volume, assessed with magnetic resonance imaging, and current number of self-reported ADHD symptoms was studied. The results showed an association between these self-reported ADHD symptoms and total brain volume. Post-hoc analysis revealed that the symptom domain of inattention had the strongest association with total brain volume. In addition, the threshold for impairment coincides with the threshold for brain volume reduction.
CONCLUSIONS/SIGNIFICANCE: This finding improves our understanding of the biological substrates of self-reported ADHD symptoms, and suggests total brain volume as a target intermediate phenotype for future gene-finding in ADHD.
Authors:
Martine Hoogman; Mark Rijpkema; Luc Janss; Han Brunner; Guillen Fernandez; Jan Buitelaar; Barbara Franke; Alejandro Arias-Vásquez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-02-10
Journal Detail:
Title:  PloS one     Volume:  7     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2012  
Date Detail:
Created Date:  2012-02-20     Completed Date:  2012-07-31     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e31273     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands. m.hoogman@psy.umcn.nl
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Attention Deficit Disorder with Hyperactivity / diagnosis,  pathology*
Brain / pathology*
Humans
Magnetic Resonance Imaging
Organ Size
Phenotype
Predictive Value of Tests
Self Report
Young Adult
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