Document Detail


Current role of radiotherapy in Hodgkin's and non-Hodgkin's lymphoma.
MedLine Citation:
PMID:  8541386     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Current goals of therapy for patients with Hodgkin's disease include maximizing cure rate while minimizing toxicity, particularly long-term toxicity such as treatment-related second cancers, pulmonary toxicity, and cardiac toxicity. For early-stage patients the need for staging laparotomy, the necessary extent of radiation therapy, and the possibilities of combined modality therapy are current controversies. For patients with stage III disease it is now clear that chemotherapy is an essential component of therapy. Long-term follow-up studies continue to show that a significant number of patients treated for Hodgkin's disease eventually develop solid tumors and acute myelogenous leukemia. Populations most at risk and treatments associated with these risks are being defined. For patients with large-cell lymphoma, anthracycline-containing chemotherapy is the mainstay of therapy, although radiation therapy to sites of bulky disease may have a role.
Authors:
L N Shulman; P M Mauch
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in oncology     Volume:  7     ISSN:  1040-8746     ISO Abbreviation:  Curr Opin Oncol     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1996-02-14     Completed Date:  1996-02-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9007265     Medline TA:  Curr Opin Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  421-5     Citation Subset:  IM    
Affiliation:
Hematology-Oncology Division, Brigham and Women's Hospital, Boston, MA 02215, USA.
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MeSH Terms
Descriptor/Qualifier:
Combined Modality Therapy
Hodgkin Disease / pathology,  radiotherapy*,  therapy
Humans
Laparotomy
Lymphoma, Large B-Cell, Diffuse / pathology,  radiotherapy
Lymphoma, Non-Hodgkin / pathology,  radiotherapy*
Neoplasm Staging
Neoplasms, Radiation-Induced / etiology
Neoplasms, Second Primary / etiology
Radiotherapy / adverse effects
Salvage Therapy
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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