Document Detail

Current reperfusion strategies for ST elevation myocardial infarction: a Canadian perspective.
MedLine Citation:
PMID:  15100755     Owner:  NLM     Status:  MEDLINE    
The goal of reperfusion therapy for ST elevation myocardial infarction is to achieve prompt and sustained patency of the infarct-related artery. Fibrinolytic therapy is quickly available but it successfully restores flow only in approximately 60% of cases. Percutaneous coronary intervention (PCI) is successful in over 90% of cases but requires timely availability of an experienced interventional team. Although individual trials do not show a clear mortality benefit with PCI, a recent analysis of 23 trials comparing PCI with fibrinolytic therapy showed PCI was associated with improved survival. PCI is also associated with less recurrent ischemia, reinfarction, stroke, target vessel revascularization and a shorter hospital stay. Facilitated PCI attempts to optimize the benefits of pharmacological and mechanical reperfusion by giving a pharmacological agent initially, hoping for reperfusion while an emergency PCI is organized. The literature regarding pharmacological and mechanical reperfusion is reviewed to emphasize the important issues while a future strategy of facilitated PCI is contemplated.
Catherine S McLellan; Michel R Le May; Marino Labinaz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Canadian journal of cardiology     Volume:  20     ISSN:  0828-282X     ISO Abbreviation:  Can J Cardiol     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-21     Completed Date:  2004-05-27     Revised Date:  2008-04-09    
Medline Journal Info:
Nlm Unique ID:  8510280     Medline TA:  Can J Cardiol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  525-33     Citation Subset:  IM    
University of Ottawa Heart Institute, Ottawa, Canada.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary
Arrhythmias, Cardiac / complications
Fibrinolytic Agents / therapeutic use
Length of Stay
Myocardial Infarction / complications,  therapy*
Myocardial Reperfusion*
Randomized Controlled Trials as Topic
Thrombolytic Therapy
Reg. No./Substance:
0/Fibrinolytic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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