| Current regimens for treatment of Helicobacter pylori infection. | |
| | |
MedLine Citation:
|
PMID: 9604443 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The aim of treatment of Helicobacter pylori is eradication of the bacterium from the foregut. Treatment is difficult because of the bacterium's habitat and acquired resistance to commonly used antibiotics. Dual therapy, the 2 week combination of omeprazole or ranitidine bismuth citrate and either amoxycillin or clarithromycin, eradicates H. pylori in 50-80% of patients. Classical triple therapy is commonly associated with side effects, is highly dependent on patient's compliance, and is significantly less effective in the presence of metronidazole-resistant strains of H. pylori, where eradication may be 50%. One week, twice daily, proton pump inhibitor (PPI)-based triple therapy regimens eradicate about 90% of H. pylori and are associated with mild side effects. Second line regimens include 7 days treatment with omeprazole and 3 times daily amoxycillin and metronidazole or a PPI-based quadruple therapy regimen. In some cases, the bacterium defeats all attempts at eradication. |
| | |
Authors:
|
A Harris |
Related Documents
:
|
22151793 - Photodynamic therapy for actinic keratosis in organ transplant patients. 21768563 - Vacuum-assisted closure therapy for reconstruction of soft-tissue forehead defects. 22151793 - Photodynamic therapy for actinic keratosis in organ transplant patients. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: British medical bulletin Volume: 54 ISSN: 0007-1420 ISO Abbreviation: Br. Med. Bull. Publication Date: 1998 |
Date Detail:
|
Created Date: 1998-06-23 Completed Date: 1998-06-23 Revised Date: 2005-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0376542 Medline TA: Br Med Bull Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 195-205 Citation Subset: IM |
Affiliation:
|
Kent and Sussex Hospital, Royal Tunbridge Wells, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amoxicillin
/
administration & dosage Antitrichomonal Agents / therapeutic use* Clarithromycin / administration & dosage Drug Therapy, Combination / therapeutic use* Helicobacter Infections / drug therapy* Helicobacter pylori* Histamine H2 Antagonists / therapeutic use* Humans Omeprazole / administration & dosage, therapeutic use Proton Pumps / antagonists & inhibitors* Ranitidine / therapeutic use Stomach Diseases / drug therapy*, microbiology Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Antitrichomonal Agents; 0/Histamine H2 Antagonists; 0/Proton Pumps; 26787-78-0/Amoxicillin; 66357-35-5/Ranitidine; 73590-58-6/Omeprazole; 81103-11-9/Clarithromycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Clinical practice--breath tests.
Next Document: Antibiotic resistance in Helicobacter pylori infection.