| Current and prospective treatment options for Sj?gren's syndrome. | |
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MedLine Citation:
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PMID: 20477575 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Sj?gren's syndrome is both an organ-specific and a systemic autoimmune disease. Patients with dry eyes and dry mouth usually receive symptomatic treatment. Topical cyclosporine A may be administered to patients with dry eyes. The efficacy of muscarinic agonists, such as pilocarpine and cevimeline, in increasing salivary and lacrimal flow and improving patient symptoms has been well documented. Mild immunomodulatory or immunosuppressive medication is preferable to prevent the mild progressive course of the disorders. Other patients who show aggressive progression to organ disorders should be managed differently. High doses of corticosteroids, immunosuppressive agents or new biological agents, such as antibodies to CD20, are required for these patients. The elimination of B lymphocytes by anti-CD20 antibodies may be highly beneficial; however, the development of more selective drugs based on the pathogenesis of the disease is required for the future treatment of Sj?gren's syndrome. |
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Authors:
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Susumu Sugai; Yasafumi Masaki |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Expert review of clinical immunology Volume: 4 ISSN: 1744-8409 ISO Abbreviation: Expert Rev Clin Immunol Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2010-05-18 Completed Date: 2010-06-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101271248 Medline TA: Expert Rev Clin Immunol Country: England |
Other Details:
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Languages: eng Pagination: 469-79 Citation Subset: - |
Affiliation:
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Kudo General Hospital, Kanazawa Medical University, Japan. sussugai@helen.ocn.ne.jp |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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