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Current pregnancy outcomes in women with cystic fibrosis.
MedLine Citation:
PMID:  22784584     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES: Women with cystic fibrosis (CF) now achieve a greater life expectancy and therefore have greater expectations from life. Literature reporting pregnancy outcomes in CF is still sparse. There remains a legacy of advising women with significant disease to avoid pregnancy. We aimed to assess current maternal and fetal outcomes in women with CF with varied pre-pregnancy lung function. STUDY DESIGN: Retrospective case note review of data from 15 pregnancies in 12 women with CF receiving care at a specialist centre between 2003 and 2011. Descriptive statistics were used for the quantitative data. The forced expiratory volume (FEV(1)) and forced vital capacity (FVC) were calculated and shown as the percentage of their predicted values for BMI, height and age. Changes in lung function pre, 6, and 24 months post delivery were calculated with the paired t-test. RESULTS: Mean maternal age was 28.9 (range 21-36, CI 26.8-31). Maternal FEV(1) at booking ranged from 27 to 80% predicted (mean=63.6%, CI 54.62-71.38%). Cystic fibrosis-related diabetes (CFRD) was present in 8 of 14 (live birth) pregnancies. Average gestation at delivery was 38 weeks. There was a 100% vaginal delivery rate (11 spontaneous vertex, 2 ventouse, 1 forceps). Average fetal birth weight was 2.97kg (range 2.2-3.83kg, CI 2.72-3.23). The differences between the maternal pre- and 6 months post-pregnancy mean FEV(1) (p=0.136) and FVC (p=0.225) were not statistically significant. CONCLUSION: With careful multidisciplinary antenatal and intrapartum management, successful outcomes have been obtained in this group of women with CF.
Authors:
Christy Burden; Rachel Ion; Yealin Chung; Amanda Henry; Damian G Downey; Johanna Trinder
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-9
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  -     ISSN:  1872-7654     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Registrar Obstetrics and Gynaecology, Maternal Medicine Department, University Hospitals Bristol, Southwell Street, Bristol BS2 8EG, UK.
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