Document Detail


Current practice of prophylactic anticoagulation in Guillain-Barré syndrome.
MedLine Citation:
PMID:  11926177     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To document the incidence of venous thromboembolism in Guillain-Barré syndrome and current practice of anticoagulating these patients. DESIGN: Retrospective study. SETTING: Acute neurology and rehabilitation wards in a teaching hospital. SUBJECTS: Seventy-three patients with Guillain-Barré syndrome admitted to Addenbrooke's Hospital from 1995 to 1999. RESULTS: Out of 73 patients, 50 were anticoagulated (68%) for 5-490 days with mean of 72 days. Anticoagulation was discontinued in 28 patients when they could walk independently and in six who were still wheelchair dependent. Five patients developed clinical deep venous thrombosis (DVT) (7%), three of them had pulmonary emboli. Venous thrombosis occurred in the first two months after onset in four patients. Two patients were not anticoagulated when they developed their DVT and the other three were on enoxaparin; one of these three had a pulmonary embolism and died. CONCLUSION: Despite prophylactic anticoagulants being used in the majority of patients admitted with major problems of mobility, 6% (3 out of 50) still developed clinically detected DVT and two developed pulmonary embolism. While this incidence is considerably lower than data reported before routine anticoagulation became a standard practice, these data reinforce the need for anticoagulation and suggest that full anticoagulation might be needed to reduce the incidence of thromboembolic complications further.
Authors:
T A Z K Gaber; S G B Kirker; J R Jenner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical rehabilitation     Volume:  16     ISSN:  0269-2155     ISO Abbreviation:  Clin Rehabil     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-03-25     Completed Date:  2002-08-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8802181     Medline TA:  Clin Rehabil     Country:  England    
Other Details:
Languages:  eng     Pagination:  190-3     Citation Subset:  IM    
Affiliation:
Addenbrooke's Hospital, Cambridge, UK. t_gaber@lycos.com
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MeSH Terms
Descriptor/Qualifier:
Anticoagulants / therapeutic use*
Female
Guillain-Barre Syndrome / complications*,  drug therapy
Heparin, Low-Molecular-Weight / therapeutic use*
Humans
Incidence
Male
Middle Aged
Pulmonary Embolism / epidemiology,  prevention & control
Retrospective Studies
Venous Thrombosis / epidemiology,  prevention & control*
Chemical
Reg. No./Substance:
0/Anticoagulants; 0/Heparin, Low-Molecular-Weight

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