Document Detail

Current mechanisms of macula densa cell signalling.
MedLine Citation:
PMID:  15283759     Owner:  NLM     Status:  MEDLINE    
Macula densa cells couple renal haemodynamics, glomerular filtration and renin release with tubular fluid salt and water reabsorption. These cells detect changes in tubular fluid composition through a complex of intracellular signalling events that are mediated by membrane transport pathways. Increases in luminal fluid sodium chloride concentration result in alterations in cell sodium chloride concentration, cytosolic calcium, cell pH, basolateral membrane depolarization and cell volume. Macula densa signalling then involves the production and release of specific paracrine signalling molecules at their basolateral membrane. Upon moderate increases in luminal sodium chloride concentration macula densa cells release increasing amounts of ATP and decreasing amounts of prostaglandin E(2), thereby increasing afferent arteriolar tone and decreasing the release of renin from granular cells. On the other hand, further increases in luminal concentration stimulate the release of nitric oxide, which serve to prevent excessive tubuloglomerular feedback vasoconstriction. Paracrine signalling by the macula densa cells therefore controls juxtaglomerular function, renal vascular resistance and participates in the regulation of renin release.
P Komlosi; A Fintha; P D Bell
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  181     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-07-30     Completed Date:  2004-09-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  England    
Other Details:
Languages:  eng     Pagination:  463-9     Citation Subset:  IM    
Department of Medicine, Division of Nephrology, University of Alabama at Birmingham, USA.
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MeSH Terms
Adenosine Triphosphate / physiology
Juxtaglomerular Apparatus / cytology
Kidney Tubules, Distal / cytology*
Paracrine Communication / physiology*
Renal Circulation / physiology*
Signal Transduction / physiology
Grant Support
32032//PHS HHS
Reg. No./Substance:
56-65-5/Adenosine Triphosphate

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