Document Detail

Current management of patients with pulmonary hypertension and right ventricular insufficiency.
MedLine Citation:
PMID:  10980899     Owner:  NLM     Status:  MEDLINE    
Pulmonary hypertension is a pathologic condition characterized by elevated pulmonary artery pressures and an associated vasculopathy. Primary pulmonary hypertension (PPH) is a rare condition with a sporadic occurrence and a familial form of the disorder. Abnormal vasomotor tone in the pulmonary vasculature results from an imbalance of the action of various vasoconstrictors/ vascular proliferative agents (endothelin and thromboxane) versus vasodilators /anti-proliferative agents (prostacyclin and nitric oxide). The mainstay of outpatient therapy has been the use of digitalis, diuretics, oxygen, and coumadin and the judicious use of vasodilator therapy. Calcium channel blockers in a select group and intravenous prostacyclin have dramatically improved survival for those with primary pulmonary hypertension. Use of prostaglandin I2 (PGI2) in other forms of chronic pulmonary arterial hypertension is not as clear, although evidence of initial beneficial response is promising. Importantly, over the next few years both pharmacologic and nonpharmacologic treatment modalities for pulmonary hypertension may rapidly change as we focus more on the abnormal pulmonary vascular biology and concomitant hemodynamic and neurohormonal milieu.
S R Hankins; E M Horn
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current cardiology reports     Volume:  2     ISSN:  1523-3782     ISO Abbreviation:  Curr Cardiol Rep     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-11-21     Completed Date:  2000-11-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100888969     Medline TA:  Curr Cardiol Rep     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  244-51     Citation Subset:  IM    
Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
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MeSH Terms
Antihypertensive Agents / therapeutic use
Cardiotonic Agents / therapeutic use
Endothelium, Vascular / physiopathology
Epoprostenol / therapeutic use
Hypertension, Pulmonary / drug therapy*,  physiopathology
Vasodilator Agents / therapeutic use
Vasomotor System / physiopathology
Ventricular Dysfunction, Right / drug therapy*,  physiopathology
Reg. No./Substance:
0/Antihypertensive Agents; 0/Cardiotonic Agents; 0/Vasodilator Agents; 35121-78-9/Epoprostenol

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