Document Detail

Current management of the infant who presents with neonatal encephalopathy.
MedLine Citation:
PMID:  21458747     Owner:  NLM     Status:  In-Data-Review    
Neonatal encephalopathy after perinatal hypoxic-ischemic insult is a major contributor to global child mortality and morbidity. Brain injury in term infants in response to hypoxic-ischemic insult is a complex process evolving over hours to days, which provides a unique window of opportunity for neuroprotective treatment interventions. Advances in neuroimaging, brain monitoring techniques, and tissue biomarkers have improved the ability to diagnose, monitor, and care for newborn infants with neonatal encephalopathy as well as predict their outcome. However, challenges remain in early identification of infants at risk for neonatal encephalopathy, determination of timing and extent of hypoxic-ischemic brain injury, as well as optimal management and treatment duration. Therapeutic hypothermia is the most promising neuroprotective intervention to date for infants with moderate to severe neonatal encephalopathy after perinatal asphyxia and has currently been incorporated in many neonatal intensive care units in developed countries. However, only 1 in 6 babies with encephalopathy will benefit from hypothermia therapy; many infants still develop significant adverse outcomes. To enhance the outcome, specific diagnostic predictors are needed to identify patients likely to benefit from hypothermia treatment. Studies are needed to determine the efficacy of combined therapeutic strategies with hypothermia therapy to achieve maximal neuroprotective effect. This review focuses on important concepts in the pathophysiology, diagnosis, and management of infants with neonatal encephalopathy due to perinatal asphyxia, including an overview of recently introduced novel therapies.
Elena V Wachtel; Karen D Hendricks-Muñoz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current problems in pediatric and adolescent health care     Volume:  41     ISSN:  1538-3199     ISO Abbreviation:  Curr Probl Pediatr Adolesc Health Care     Publication Date:    2011 May-Jun
Date Detail:
Created Date:  2011-04-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101134613     Medline TA:  Curr Probl Pediatr Adolesc Health Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  132-53     Citation Subset:  IM    
Copyright Information:
Published by Mosby, Inc.
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