Document Detail

Current and lifetime psychiatric illness in women with Turner syndrome.
MedLine Citation:
PMID:  15726728     Owner:  NLM     Status:  MEDLINE    
Abnormalities in quality of life and cognitive measures have been observed in women with Turner syndrome (TS), and a relationship between these phenomena and chromosomal constitution has been suggested. In contrast, few studies have systematically evaluated the presence of mood and behavioral syndromes in these women. In this study, 100 TS women were administered the Structured Clinical Interview for DSM IV after a two-week period during which their hormone replacement had been discontinued. The majority of women who met criteria for a psychiatric condition had a mood or anxiety disorder. Overall, 52 (52%) of the TS women met criteria for a current or a past depressive or anxiety disorder. Eighteen of the women with TS met criteria for a current Axis I psychiatric disorder [Depression--major (n = 5), minor (n = 5), dysthymia (n = 1); Anxiety (n = 9)]. Forty-six of the women with TS met criteria for a past Axis I psychiatric illness [Depression: unipolar (n = 41), bipolar (n = 3); Anxiety (n= 7); eating disorder (n =6); substance dependence (n = 3)]. Five women with TS met criteria for an Axis II personality disorder. Women with TS reported a higher rate of lifetime depression compared with rates observed in community-based studies but similar to those obtained from gynecologic clinic samples.
Graca Cardoso; Robert Daly; Nazli A Haq; Lori Hanton; David R Rubinow; Carolyn A Bondy; Peter Schmidt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology     Volume:  19     ISSN:  0951-3590     ISO Abbreviation:  Gynecol. Endocrinol.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2005-02-23     Completed Date:  2005-03-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807913     Medline TA:  Gynecol Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  313-9     Citation Subset:  IM    
Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Department of Health & Human Services, Bethesda, MD 20892-1276, USA.
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MeSH Terms
Anxiety / epidemiology
Depression / epidemiology
Eating Disorders / epidemiology
Estrogen Replacement Therapy
Hormone Replacement Therapy
Human Growth Hormone / administration & dosage
Mental Disorders / complications,  diagnosis,  epidemiology*
Middle Aged
Mood Disorders / epidemiology
Thyroid Hormones / administration & dosage
Turner Syndrome / genetics,  psychology*
Reg. No./Substance:
0/Thyroid Hormones; 12629-01-5/Human Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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