Document Detail

Current knowledge in the renewal capability of germ cells in the adult ovary.
MedLine Citation:
PMID:  19306347     Owner:  NLM     Status:  MEDLINE    
It is a central dogma in reproductive biology that oogenesis is completed before or just after birth and that the postnatal ovary is endowed by a fixed and non-renewing number of oocytes in mammals. However, this widely accepted doctrine was recently challenged by studies showing regeneration of oocytes from putative germ cells in bone marrow and peripheral blood. These results not only triggered an enormous amount of interest among reproductive biologists but also a great deal of debate. In this review we will provide an update on the molecular aspects of the formation of primordial germ cells (PGC), the precursors of adult gametocytes, beginning from their specification to their migration to prospective gonads and formation of the ovary and follicular structures. We will also discuss more recent studies that showed in vivo regeneration of germ cells in the postnatal ovary in situ, along with other pioneering works that demonstrated generation of germ cells in vitro from embryonic and somatic stem cells.
Ozgur Oktem; Kutluk Oktay
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Birth defects research. Part C, Embryo today : reviews     Volume:  87     ISSN:  1542-9768     ISO Abbreviation:  Birth Defects Res. C Embryo Today     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-04-07     Completed Date:  2009-06-05     Revised Date:  2012-07-12    
Medline Journal Info:
Nlm Unique ID:  101167665     Medline TA:  Birth Defects Res C Embryo Today     Country:  United States    
Other Details:
Languages:  eng     Pagination:  90-5     Citation Subset:  IM    
Laboratory of Molecular Reproduction and Fertility Preservation, Department of Obstetrics and Gynecology, New York Medical College, Valhalla, New York 10595, USA.
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MeSH Terms
Cell Movement / physiology
Oocytes / physiology*
Oogenesis / physiology*
Ovary / physiology*
Stem Cells / physiology*

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