Document Detail


Current knowledge of the aetiology of human tubal ectopic pregnancy.
MedLine Citation:
PMID:  20071358     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND An ectopic pregnancy is a pregnancy which occurs outside of the uterine cavity, and over 98% implant in the Fallopian tube. Tubal ectopic pregnancy remains the most common cause of maternal mortality in the first trimester of pregnancy. The epidemiological risk factors for tubal ectopic pregnancy are well established and include: tubal damage as a result of surgery or infection (particularly Chlamydia trachomatis), smoking and in vitro fertilization. This review appraises the data to date researching the aetiology of tubal ectopic pregnancy. METHODS Scientific literature was searched for studies investigating the underlying aetiology of tubal ectopic pregnancy. RESULTS Existing data addressing the underlying cause of tubal ectopic pregnancy are mostly descriptive. There are currently few good animal models of tubal ectopic pregnancy. There are limited data explaining the link between risk factors and tubal implantation. CONCLUSIONS Current evidence supports the hypothesis that tubal ectopic pregnancy is caused by a combination of retention of the embryo within the Fallopian tube due to impaired embryo-tubal transport and alterations in the tubal environment allowing early implantation to occur. Future studies are needed that address the functional consequences of infection and smoking on Fallopian tube physiology. A greater understanding of the aetiology of tubal ectopic pregnancy is critical for the development of improved preventative measures, the advancement of diagnostic screening methods and the development of novel treatments.
Authors:
J L V Shaw; S K Dey; H O D Critchley; A W Horne
Related Documents :
3421278 - Sterilization reversal: results of 101 attempts.
2523828 - The significance of preoperative hysterosalpingography and laparoscopy for predicting t...
3630568 - Surgical management of tubal obstruction at the uterotubal junction.
11328538 - Tubal ectopic pregnancy associated with an adenomatoid tumor.
18291518 - Detection of leptospira spp. in semen and vaginal fluids of goats and sheep by polymera...
11826768 - Pheochromocytoma in a pregnant woman with multiple endocrine neoplasia type 2a.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2010-01-12
Journal Detail:
Title:  Human reproduction update     Volume:  16     ISSN:  1460-2369     ISO Abbreviation:  Hum. Reprod. Update     Publication Date:    2010 Jul-Aug
Date Detail:
Created Date:  2010-06-07     Completed Date:  2010-09-14     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  9507614     Medline TA:  Hum Reprod Update     Country:  England    
Other Details:
Languages:  eng     Pagination:  432-44     Citation Subset:  IM    
Affiliation:
Centre for Reproductive Biology, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Chlamydia Infections / complications
Chlamydia trachomatis
Embryo Implantation / drug effects
Fallopian Tubes / physiopathology*
Female
Humans
Mice
Pregnancy
Pregnancy, Tubal / diagnosis,  epidemiology,  etiology*
Rats
Smoking
Grant Support
ID/Acronym/Agency:
DA DA06668/DA/NIDA NIH HHS; G0802808//Medical Research Council; G0802808(90914)//Medical Research Council; //Medical Research Council
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Human studies on genetics of the age at natural menopause: a systematic review.
Next Document:  Photosynthesis of young apple trees in response to low sink demand under different air temperatures.