| Current issues of selenium in cancer chemoprevention. | |
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MedLine Citation:
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PMID: 20333751 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The element selenium (Se) was identified, nearly 40 years ago, as being essential in the nutrition of animals and humans. In addition, antitumorigenic effects of Se compounds have been described in a variety of in vitro and animal models, suggesting that supplemental Se in human diets may reduce cancer risk. Apparent mechanisms underlying the potential of Se compounds as cancer chemopreventive agents have been suggested. Some recent clinical trials, however, have shed doubt on the anticancer effects of Se. The contradictory findings and consequent controversy might be due to the lack of understanding of the mechanisms underlying Se biology. This article reviews current knowledge on this topic and addresses the disparate viewpoints on the chemopreventive effects of Se, the human populations. |
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Authors:
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Hwa Jin Jung; Young R Seo |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: BioFactors (Oxford, England) Volume: 36 ISSN: 1872-8081 ISO Abbreviation: Biofactors Publication Date: 2010 Mar-Apr |
Date Detail:
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Created Date: 2010-04-14 Completed Date: 2010-06-28 Revised Date: 2010-12-20 |
Medline Journal Info:
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Nlm Unique ID: 8807441 Medline TA: Biofactors Country: Netherlands |
Other Details:
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Languages: eng Pagination: 153-8 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Biomedical Science Institute, School of Medicine, Kyung Hee University, Dongdaemun-gu, Seoul, South Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chemoprevention / methods* Humans Neoplasms / prevention & control* Selenium / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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7782-49-2/Selenium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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