Document Detail


Current issues and perspectives in hypoplasia of the left heart.
MedLine Citation:
PMID:  15831164     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hypoplastic left heart syndrome is a rare but serious form of congenital cardiac disease, characterized by underdevelopment of the components of the left heart, rendering the left ventricle non-functional. Its aetiology is largely unknown, but there is certainly a genetic component. Prenatal diagnosis nowadays uncovers about half of cases. Postnatal options for treatment include comfort care, 3-stage palliative surgery, or cardiac transplantation. In this review, we discuss the morphology, possible pathogenetic mechanisms, clinical management, and perspectives of prenatal intervention based on work in animal models.
Authors:
David Sedmera; Andrew C Cook; Girish Shirali; Tim C McQuinn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Cardiology in the young     Volume:  15     ISSN:  1047-9511     ISO Abbreviation:  Cardiol Young     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-04-15     Completed Date:  2005-05-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9200019     Medline TA:  Cardiol Young     Country:  England    
Other Details:
Languages:  eng     Pagination:  56-72     Citation Subset:  IM    
Affiliation:
Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina 29425, USA. sedmerad@musc.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Aortic Valve / pathology
Aortic Valve Stenosis / pathology
Coronary Circulation
Disease Models, Animal
Echocardiography, Doppler
Fetus / surgery
Heart Septal Defects, Ventricular / pathology
Humans
Hypoplastic Left Heart Syndrome* / diagnosis,  pathology,  physiopathology,  surgery
Infant
Mitral Valve / pathology
Prenatal Diagnosis
Vascular Resistance
Grant Support
ID/Acronym/Agency:
HL067135/HL/NHLBI NIH HHS; RR16434/RR/NCRR NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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