| Current issues and perspectives in hypoplasia of the left heart. | |
MedLine Citation:
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PMID: 15831164 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypoplastic left heart syndrome is a rare but serious form of congenital cardiac disease, characterized by underdevelopment of the components of the left heart, rendering the left ventricle non-functional. Its aetiology is largely unknown, but there is certainly a genetic component. Prenatal diagnosis nowadays uncovers about half of cases. Postnatal options for treatment include comfort care, 3-stage palliative surgery, or cardiac transplantation. In this review, we discuss the morphology, possible pathogenetic mechanisms, clinical management, and perspectives of prenatal intervention based on work in animal models. |
Authors:
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David Sedmera; Andrew C Cook; Girish Shirali; Tim C McQuinn |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Cardiology in the young Volume: 15 ISSN: 1047-9511 ISO Abbreviation: Cardiol Young Publication Date: 2005 Feb |
Date Detail:
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Created Date: 2005-04-15 Completed Date: 2005-05-12 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9200019 Medline TA: Cardiol Young Country: England |
Other Details:
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Languages: eng Pagination: 56-72 Citation Subset: IM |
Affiliation:
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Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina 29425, USA. sedmerad@musc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aortic Valve / pathology Aortic Valve Stenosis / pathology Coronary Circulation Disease Models, Animal Echocardiography, Doppler Fetus / surgery Heart Septal Defects, Ventricular / pathology Humans Hypoplastic Left Heart Syndrome* / diagnosis, pathology, physiopathology, surgery Infant Mitral Valve / pathology Prenatal Diagnosis Vascular Resistance |
| Grant Support | |
ID/Acronym/Agency:
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HL067135/HL/NHLBI NIH HHS; RR16434/RR/NCRR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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