Document Detail

Current issues and perspectives in hypoplasia of the left heart.
MedLine Citation:
PMID:  15831164     Owner:  NLM     Status:  MEDLINE    
Hypoplastic left heart syndrome is a rare but serious form of congenital cardiac disease, characterized by underdevelopment of the components of the left heart, rendering the left ventricle non-functional. Its aetiology is largely unknown, but there is certainly a genetic component. Prenatal diagnosis nowadays uncovers about half of cases. Postnatal options for treatment include comfort care, 3-stage palliative surgery, or cardiac transplantation. In this review, we discuss the morphology, possible pathogenetic mechanisms, clinical management, and perspectives of prenatal intervention based on work in animal models.
David Sedmera; Andrew C Cook; Girish Shirali; Tim C McQuinn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Cardiology in the young     Volume:  15     ISSN:  1047-9511     ISO Abbreviation:  Cardiol Young     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-04-15     Completed Date:  2005-05-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9200019     Medline TA:  Cardiol Young     Country:  England    
Other Details:
Languages:  eng     Pagination:  56-72     Citation Subset:  IM    
Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina 29425, USA.
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MeSH Terms
Aortic Valve / pathology
Aortic Valve Stenosis / pathology
Coronary Circulation
Disease Models, Animal
Echocardiography, Doppler
Fetus / surgery
Heart Septal Defects, Ventricular / pathology
Hypoplastic Left Heart Syndrome* / diagnosis,  pathology,  physiopathology,  surgery
Mitral Valve / pathology
Prenatal Diagnosis
Vascular Resistance
Grant Support

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