| Current evidence for a role of GLP-1 in Roux-en-Y gastric bypass-induced remission of type 2 diabetes. | |
| | |
MedLine Citation:
|
PMID: 21951387 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Weight reducing surgical procedures such as Roux-en-Y gastric bypass (RYGB) have proven efficient as means of decreasing excess body weight. Furthermore, some studies report that up to 80% of patients with type 2 diabetes mellitus (T2DM) undergoing RYGB experience complete remission of their T2DM. Interestingly, the majority of remissions occur almost immediately following the operation and long before significant weight loss has taken place. Following RYGB dramatic increases in postprandial plasma concentrations of the incretin hormone glucagon-like peptide-1 (GLP-1) have been recorded; and the known anti-diabetic effects of GLP-1 are thought to be key mediators in RYGB-induced remission of T2DM. However, the published studies on the impact of RYGB on GLP-1 secretion are few, small, and often not controlled properly. Furthermore, mechanistic studies delineating the role of endogenous GLP-1 secretion in RYGB-induced remission of T2DM are lacking. This paper critically evaluates the current evidence for a role of GLP-1 in Roux-en-Y gastric bypass-induced remission of T2DM. |
| | |
Authors:
|
Nicolai A Rhee; Tina Vilsbøll; Filip K Knop |
Related Documents
:
|
3666317 - Altered protein phosphorylation in sciatic nerve from rats with streptozocin-induced di... 17121317 - Myoinositol/folic acid combination for the treatment of erectile dysfunction in type 2 ... 3115267 - Development of potent aldose reductase inhibitors having a hydantoin structure. 11191927 - Electrodiagnosis of polyneuropathy. 6753617 - Pancreatic endocrine function after total gastrectomy and truncal vagotomy. 4029757 - Combined dys-form of homozygous factor xi deficiency and heterozygous factor xii defici... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-9-26 |
Journal Detail:
|
Title: Diabetes, obesity & metabolism Volume: - ISSN: 1463-1326 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-9-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100883645 Medline TA: Diabetes Obes Metab Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2011 Blackwell Publishing Ltd. |
Affiliation:
|
1Diabetes Research Division, Department of Internal Medicine F, Gentofte Hospital, University of Copenhagen. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: ACUTE RENAL FAILURE IN ACUTE POISONING: PROSPECTIVE STUDY FROM A TERTIARY CARE CENTRE OF SOUTH INDIA...
Next Document: An overview of cancer/testis antigens expression in classical Hodgkin's lymphoma (cHL) identifies MA...