Document Detail


Current enoxaparin dosing guidelines have dubious credibility.
MedLine Citation:
PMID:  20581896     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To assess the prescribing practice of enoxaparin in comparison to dosing guidelines. METHOD: A prospective observational chart review of patients who received enoxaparin for the treatment of thrombosis at Dunedin Public Hospital between August 2007 and January 2008. Deviations in dose from guidelines were defined and recorded along with various clinical and demographic data of participants. RESULTS: Fifty-nine patients (62 admissions) were recruited. Dose deviations occurred on 19 (30.7%) occasions. More dose deviations occurred at or close to guideline transition points (total body weight over 90 kg and/or creatinine clearance between 20-40 mL/min). CONCLUSION: Current enoxaparin dosing guidelines are too simplistic and result in discord between dosing in practice and that approved by Medsafe.
Authors:
Hesham Al-Sallami; Sarah Jordan; Ruth Ferguson; Natalie Medlicott; John Schollum; Stephen Duffull
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-04-30
Journal Detail:
Title:  The New Zealand medical journal     Volume:  123     ISSN:  1175-8716     ISO Abbreviation:  N. Z. Med. J.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-06-28     Completed Date:  2010-07-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401067     Medline TA:  N Z Med J     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  62-7     Citation Subset:  IM    
Affiliation:
School of Pharmacy, University of Otago, PO Box 56, Dunedin, New Zealand. hesham.al-sallami@otago.ac.nz
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MeSH Terms
Descriptor/Qualifier:
Anticoagulants / administration & dosage
Drug Prescriptions / standards*
Enoxaparin / administration & dosage*
Humans
Practice Guidelines as Topic*
Thrombosis / drug therapy*
Chemical
Reg. No./Substance:
0/Anticoagulants; 0/Enoxaparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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