Document Detail


Current developments in salivary diagnostics.
MedLine Citation:
PMID:  20387312     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Salivary diagnostics is an emerging field that has progressed through several important developments in the past decade, including the publication of the human salivary proteome and the infusion of federal funds to integrate nanotechnologies and microfluidic engineering concepts into developing compact point-of-care devices for rapid analysis of this secretion. In this article, we discuss some of these developments and their relevance to the prognosis, diagnosis and management of periodontitis, as an oral target, and cardiovascular disease, as a systemic example for the potential of these biodiagnostics. Our findings suggest that several biomarkers are associated with distinct biological stages of these diseases and demonstrate promise as practical biomarkers in identifying and managing periodontal disease, and acute myocardial infarction. The majority of these studies have progressed through biomarker discovery, with the identified molecules requiring more robust clinical studies to enable substantive validation for disease diagnosis. It is predicted that with continued advances in this field the use of a combination of biomarkers in multiplex panels is likely to yield accurate screening tools for these diagnoses in the near future.
Authors:
Craig S Miller; Joseph D Foley; Alison L Bailey; Charles L Campell; Roger L Humphries; Nicolaos Christodoulides; Pierre N Floriano; Glennon Simmons; Bryon Bhagwandin; James W Jacobson; Spencer W Redding; Jeffrey L Ebersole; John T McDevitt
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Biomarkers in medicine     Volume:  4     ISSN:  1752-0363     ISO Abbreviation:  Biomark Med     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-04-13     Completed Date:  2010-05-03     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  101312535     Medline TA:  Biomark Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  171-89     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Biological Markers / analysis*
Bone Remodeling / physiology
Cardiovascular Diseases / diagnosis,  metabolism
Connective Tissue / chemistry
Humans
Inflammation Mediators / analysis
Lab-On-A-Chip Devices
Periodontal Diseases / diagnosis,  metabolism
Proteome
Saliva / chemistry*
Grant Support
ID/Acronym/Agency:
U01 DE017793/DE/NIDCR NIH HHS; U01 DE017793/DE/NIDCR NIH HHS; U01 DE017793-01/DE/NIDCR NIH HHS; U01 DE017793-02/DE/NIDCR NIH HHS; U01 DE017793-03/DE/NIDCR NIH HHS; U01 DE017793-04/DE/NIDCR NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Inflammation Mediators; 0/Proteome
Comments/Corrections

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