Document Detail


Current development of podophyllotoxins.
MedLine Citation:
PMID:  7044596     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The unique biological properties and therapeutic efficacy of the podophyllotoxin derivatives, Vumon (VM26, teniposide) and Vepesid (VP16-213, etoposide), are stimulating the interest of both laboratory and clinical researchers. Investigations on new pharmaceutical formulations, pharmacokinetics and metabolism are providing more appropriate information in drug administration; experimental chemotherapy indicates that, among others, cytosine arabinoside and cisplatin are highly synergistic with podophyllotoxins; single agent and combination treatment clinical trials are defining the respective role of Vumon and Vepesid in cancer chemotherapy.
Authors:
R Canetta; P Hilgard; S Florentine; P Bedogni; L Lenaz
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cancer chemotherapy and pharmacology     Volume:  7     ISSN:  0344-5704     ISO Abbreviation:  Cancer Chemother. Pharmacol.     Publication Date:  1982  
Date Detail:
Created Date:  1982-08-26     Completed Date:  1982-08-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7806519     Medline TA:  Cancer Chemother Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  93-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Chemistry, Pharmaceutical
Drug Compounding
Drug Stability
Drug Synergism
Drug Therapy, Combination
Etoposide / metabolism,  pharmacology*
Humans
Kinetics
Podophyllotoxin / analogs & derivatives*
Teniposide / metabolism*,  pharmacology*
Chemical
Reg. No./Substance:
29767-20-2/Teniposide; 33419-42-0/Etoposide; 518-28-5/Podophyllotoxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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