Document Detail

Current concepts underlying benefits of exercise training in congestive heart failure patients.
MedLine Citation:
PMID:  21532776     Owner:  NLM     Status:  PubMed-not-MEDLINE    
The pathophysiology of several conditions including heart failure is partly attributable to a failure of the cell energy metabolism. Studies have shown that exercise training (ET) improves quality of life (QOL) and is beneficial in terms of reduction of symptoms, mortality and duration of hospitalization. Increasingly, ET is now achieving acceptance as complimentary therapy in addition to routine clinical practice in patients with chronic heart failure (CHF). However, the mechanisms underlying the beneficial effects of ET are far less understood and need further evaluation. Evidence suggests that while CHF induces generalized metabolic energy depletion, ET largely enhances the overall function of the heart muscle. Hence, research efforts are now aiming to uncover why ET is beneficial as a complimentary treatment of CHF in the context of improving endothelial function and coronary perfusion, decreasing peripheral resistance, induction of cardiac and skeletal muscle cells remodeling, increasing oxygen uptake, substrate oxidation, and resistance to fatigue. Here we discuss the current evidence that suggest that there are beneficial effects of ET on cardiac and skeletal muscle cells oxidative metabolism and intracellular energy transfer in patients with CHF.
Maqsood Elahi; Mohsin Mahmood; Ahmad Shahbaz; Naveed Malick; Jawad Sajid; Sanjay Asopa; Bashir M Matata
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current cardiology reviews     Volume:  6     ISSN:  1875-6557     ISO Abbreviation:  Curr Cardiol Rev     Publication Date:  2010 May 
Date Detail:
Created Date:  2011-05-02     Completed Date:  2011-07-14     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101261935     Medline TA:  Curr Cardiol Rev     Country:  United Arab Emirates    
Other Details:
Languages:  eng     Pagination:  104-11     Citation Subset:  -    
Wessex Cardiothoracic Centre, General/ BUPA, Chalybeate Close, Southampton, SO16 6UY, United Kingdom.
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