| Current concepts and perspectives of renal volume regulation in relationship to hypertension. | |
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MedLine Citation:
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PMID: 3534185 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The renal-body fluid mechanism for arterial pressure control is almost certainly the most primitive of all the pressure-regulating mechanisms in animals. Through the stages of evolution, the system has been greatly improved. Nervous controls provide rapid pressure-control mechanisms that function almost instantaneously, many hours or days before the renal-body fluid mechanism can act fully. The renin-angiotensin-aldosterone system plays another important role: this system ensures that very large changes in salt intake, from as little as one-tenth normal up to as high as 10 times normal, have very little effect on the regulated level of the arterial pressure. Finally, the long-term autoregulatory mechanism helps to dissociate the long-term control of cardiac output from long-term control of arterial pressure; it also makes it possible for extremely slight increases in body fluid volume to cause chronic volume-loading hypertension. |
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Authors:
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A C Guyton; R D Manning; R A Norman; J P Montani; T E Lohmeier; J E Hall |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of hypertension. Supplement : official journal of the International Society of Hypertension Volume: 4 ISSN: 0952-1178 ISO Abbreviation: J Hypertens Suppl Publication Date: 1986 Oct |
Date Detail:
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Created Date: 1986-12-16 Completed Date: 1986-12-16 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8501422 Medline TA: J Hypertens Suppl Country: ENGLAND |
Other Details:
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Languages: eng Pagination: S49-56 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone
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physiology Blood Pressure Blood Volume Diet Extracellular Space / physiology Homeostasis Humans Hypertension, Renovascular / physiopathology* Kidney / physiopathology* Sodium / administration & dosage, physiology Vascular Resistance Water-Electrolyte Balance* |
| Chemical | |
Reg. No./Substance:
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52-39-1/Aldosterone; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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