Document Detail

Current concepts and perspectives of renal volume regulation in relationship to hypertension.
MedLine Citation:
PMID:  3534185     Owner:  NLM     Status:  MEDLINE    
The renal-body fluid mechanism for arterial pressure control is almost certainly the most primitive of all the pressure-regulating mechanisms in animals. Through the stages of evolution, the system has been greatly improved. Nervous controls provide rapid pressure-control mechanisms that function almost instantaneously, many hours or days before the renal-body fluid mechanism can act fully. The renin-angiotensin-aldosterone system plays another important role: this system ensures that very large changes in salt intake, from as little as one-tenth normal up to as high as 10 times normal, have very little effect on the regulated level of the arterial pressure. Finally, the long-term autoregulatory mechanism helps to dissociate the long-term control of cardiac output from long-term control of arterial pressure; it also makes it possible for extremely slight increases in body fluid volume to cause chronic volume-loading hypertension.
A C Guyton; R D Manning; R A Norman; J P Montani; T E Lohmeier; J E Hall
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of hypertension. Supplement : official journal of the International Society of Hypertension     Volume:  4     ISSN:  0952-1178     ISO Abbreviation:  J Hypertens Suppl     Publication Date:  1986 Oct 
Date Detail:
Created Date:  1986-12-16     Completed Date:  1986-12-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8501422     Medline TA:  J Hypertens Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  S49-56     Citation Subset:  IM    
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MeSH Terms
Aldosterone / physiology
Blood Pressure
Blood Volume
Extracellular Space / physiology
Hypertension, Renovascular / physiopathology*
Kidney / physiopathology*
Sodium / administration & dosage,  physiology
Vascular Resistance
Water-Electrolyte Balance*
Reg. No./Substance:
52-39-1/Aldosterone; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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