Document Detail

Current concepts of pathogenesis of otitis media: a review.
MedLine Citation:
PMID:  3072828     Owner:  NLM     Status:  MEDLINE    
A number of important factors singly or in combination contribute to the pathogenesis of otitis media. These are poor tubal function, upper respiratory viral infection, bacterial adherence and nasopharyngeal flora, and immune status of the host. One of the important functions of the tubotympanum is to protect the middle ear from invading microbes. The host has available a number of strategies for this function including mucociliary protection, antibacterial secretory products, and specific immunodefenses. The microbes also possess the capability of escaping host defenses by enhancing their ability to adhere to mucosal surfaces, impairing mucociliary function and evading phagocytosis. Once microbes gain entrance to the middle ear, the microbes must overcome phagocytosis and immunodefense of the host, leading to otitis media. Recent data further indicate that specific qualitative and quantitative deficiencies in the immune system of children may predispose certain children to develop otitis media. These deficiencies appear to be in part due to a lack of maturity of the child's developing immune system as well as functional defects that are attributable to genetic or other unknown factors.
D J Lim; T F DeMaria; L O Bakaletz
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Acta oto-laryngologica. Supplementum     Volume:  458     ISSN:  0365-5237     ISO Abbreviation:  Acta Otolaryngol Suppl     Publication Date:  1988  
Date Detail:
Created Date:  1989-06-01     Completed Date:  1989-06-01     Revised Date:  2008-02-13    
Medline Journal Info:
Nlm Unique ID:  0370355     Medline TA:  Acta Otolaryngol Suppl     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  174-80     Citation Subset:  IM    
Department of Otolaryngology, Ohio State University College of Medicine, Columbus.
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MeSH Terms
Bacterial Adhesion
Ear, Middle / physiology
Nasopharynx / microbiology
Otitis Media / etiology*
Respiratory Tract Infections / complications
Grant Support

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