| Current concepts in stem cell therapy for articular cartilage repair. | |
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MedLine Citation:
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PMID: 23320740 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Introduction: Hyaline articular cartilage is the connective tissue responsible for frictionless joint movement. Its degeneration ultimately results in complete loss of joint function in the late stages of osteoarthritis. Intrinsic repair is compromised, and cartilage tissue regeneration is difficult. However, new options are available to repair cartilage tissue by applying ESCs, MSCs and CPCs. Areas covered: In this review, the authors shed light on the different concepts currently under investigation for cartilage repair. Expert opinion: So far, there is no way to derive a chondrogenic lineage from stem cells that forms functional hyaline cartilage tissue in vivo. One alternative might be to enhance the chondrogenic potential of repair cells, which are already present in diseased cartilage tissue. CPCs found in diseased cartilage tissue in situ are biologically driven toward the osteochondrogenic lineage and can be directed toward chondrogenesis at least in vitro. |
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Authors:
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Hayat Muhammad; Boris Schminke; Nicolai Miosge |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-16 |
Journal Detail:
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Title: Expert opinion on biological therapy Volume: - ISSN: 1744-7682 ISO Abbreviation: Expert Opin Biol Ther Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101125414 Medline TA: Expert Opin Biol Ther Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Georg August University, Tissue Regeneration Work Group, Department of Prosthodontics , Robert-Koch-Str. 40, 37075, Goettingen , Germany nmiosge@gwdg.de. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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