Document Detail


Current concepts in long QT syndrome.
MedLine Citation:
PMID:  11050278     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sudden cardiac death occurs in the United States with an incidence of more than 300,000 persons per year. The underlying cause of death is commonly considered to be due to primary or secondary arrhythmias. In young persons in whom no structural heart disease can be identified, the long QT syndromes (LQTS) are commonly considered as likely causes. Multiple genes causing LQTS have been identified thus far, all of which encode cardiac ion channels. These include two potassium channel alpha subunits (KVLQT1 and HERG), two potassium channel beta subunits (minK and MiRP1), and one sodium channel gene (SCN5A). The purpose of this review is to describe the current understanding of the molecular genetics of LQTS and the resultant phenotypes, particularly in young patients.
Authors:
H Li; J Fuentes-Garcia; J A Towbin
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Pediatric cardiology     Volume:  21     ISSN:  0172-0643     ISO Abbreviation:  Pediatr Cardiol     Publication Date:    2000 Nov-Dec
Date Detail:
Created Date:  2000-12-12     Completed Date:  2000-12-12     Revised Date:  2008-02-20    
Medline Journal Info:
Nlm Unique ID:  8003849     Medline TA:  Pediatr Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  542-50     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Texas Children's Hospital and Baylor College of Medicine, Houston, TX 77030, USA.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Antagonists / therapeutic use
Animals
Child
Chromosome Mapping
Death, Sudden, Cardiac / etiology
Disease Models, Animal
Electrocardiography
Humans
Ion Channels / genetics
Long QT Syndrome / genetics*,  mortality,  therapy
Mutation
Phenotype
Potassium / therapeutic use
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Ion Channels; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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