| Current concepts in long QT syndrome. | |
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MedLine Citation:
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PMID: 11050278 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sudden cardiac death occurs in the United States with an incidence of more than 300,000 persons per year. The underlying cause of death is commonly considered to be due to primary or secondary arrhythmias. In young persons in whom no structural heart disease can be identified, the long QT syndromes (LQTS) are commonly considered as likely causes. Multiple genes causing LQTS have been identified thus far, all of which encode cardiac ion channels. These include two potassium channel alpha subunits (KVLQT1 and HERG), two potassium channel beta subunits (minK and MiRP1), and one sodium channel gene (SCN5A). The purpose of this review is to describe the current understanding of the molecular genetics of LQTS and the resultant phenotypes, particularly in young patients. |
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Authors:
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H Li; J Fuentes-Garcia; J A Towbin |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Pediatric cardiology Volume: 21 ISSN: 0172-0643 ISO Abbreviation: Pediatr Cardiol Publication Date: 2000 Nov-Dec |
Date Detail:
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Created Date: 2000-12-12 Completed Date: 2000-12-12 Revised Date: 2008-02-20 |
Medline Journal Info:
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Nlm Unique ID: 8003849 Medline TA: Pediatr Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 542-50 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Texas Children's Hospital and Baylor College of Medicine, Houston, TX 77030, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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therapeutic use Animals Child Chromosome Mapping Death, Sudden, Cardiac / etiology Disease Models, Animal Electrocardiography Humans Ion Channels / genetics Long QT Syndrome / genetics*, mortality, therapy Mutation Phenotype Potassium / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Ion Channels; 7440-09-7/Potassium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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