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Current concepts in F18 FDG PET/CT-based radiation therapy planning for lung cancer.
MedLine Citation:
PMID:  22798989     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Radiation therapy is an important component of cancer therapy for early stage as well as locally advanced lung cancer. The use of F18 FDG PET/CT has come to the forefront of lung cancer staging and overall treatment decision-making. FDG PET/CT parameters such as standard uptake value and metabolic tumor volume provide important prognostic and predictive information in lung cancer. Importantly, FDG PET/CT for radiation planning has added biological information in defining the gross tumor volume as well as involved nodal disease. For example, accurate target delineation between tumor and atelectasis is facilitated by utilizing PET and CT imaging. Furthermore, there has been meaningful progress in incorporating metabolic information from FDG PET/CT imaging in radiation treatment planning strategies such as radiation dose escalation based on standard uptake value thresholds as well as using respiratory-gated PET and CT planning for improved target delineation of moving targets. In addition, PET/CT-based follow-up after radiation therapy has provided the possibility of early detection of local as well as distant recurrences after treatment. More research is needed to incorporate other biomarkers such as proliferative and hypoxia biomarkers in PET as well as integrating metabolic information in adaptive, patient-centered, tailored radiation therapy.
Authors:
Percy Lee; Patrick Kupelian; Johannes Czernin; Partha Ghosh
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Publication Detail:
Type:  Journal Article     Date:  2012-07-11
Journal Detail:
Title:  Frontiers in oncology     Volume:  2     ISSN:  2234-943X     ISO Abbreviation:  Front Oncol     Publication Date:  2012  
Date Detail:
Created Date:  2012-07-16     Completed Date:  2012-08-23     Revised Date:  2013-08-13    
Medline Journal Info:
Nlm Unique ID:  101568867     Medline TA:  Front Oncol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  71     Citation Subset:  -    
Affiliation:
Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
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