| Current concepts on the effect of environmental factors on cleft lip and palate. | |
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MedLine Citation:
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PMID: 23228693 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The aim of this study was to investigate the effect of environmental factors, such as tobacco, alcohol and folic acid intake, obesity, stressful events, low blood levels of zinc and fever during pregnancy, on the incidence of cleft lip and/or palate (CL±P). An electronic search was performed in the Cochrane Reviews, the ISI Web of Knowledge, PubMed and Scopus, along with a manual search to identify other relevant case-control and cohort studies. Quality assessments and an evaluation of publication bias were undertaken. Statistical heterogeneity was examined, and odds ratios (ORs) and 95% confidence intervals (CI) estimated using the random effects model. Of 372 articles initially retrieved, 28 studies were selected as eligible for meta-analysis. No evidence of publication bias was found using funnel plot analysis and the Egger linear regression method. Many studies were classified as low quality due to inadequate case-control data. On the basis of this research, maternal factors most associated with CL±P were: tobacco (OR 1.48), alcohol (OR 1.28), folic acid intake (OR 0.77), obesity (OR 1.26), stressful events (OR 1.41), low blood zinc levels (OR 1.82), and fever during pregnancy (OR 1.30). Folic acid intake by the mother reduced the risk of CL±P in offspring (OR 0.77). |
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Authors:
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R Molina-Solana; R-M Yáñez-Vico; A Iglesias-Linares; A Mendoza-Mendoza; E Solano-Reina |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-7 |
Journal Detail:
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Title: International journal of oral and maxillofacial surgery Volume: - ISSN: 1399-0020 ISO Abbreviation: Int J Oral Maxillofac Surg Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8605826 Medline TA: Int J Oral Maxillofac Surg Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier Ltd. |
Affiliation:
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School of Dentistry, University of Seville, Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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