Document Detail

Current antiviral combination therapy for chronic hepatitis C patients who failed to interferon alfa-based treatment.
MedLine Citation:
PMID:  21175705     Owner:  NLM     Status:  MEDLINE    
WHAT IS KNOWN AND OBJECTIVE: Interferon-alfa-based therapy is effective in the treatment of Hepatitis C. However, some patients fail to respond and others relapse, after initially responding. Our objective was to assess the efficacy, safety and predictive factors for sustained virological response (SVR) to peginterferon plus ribavirin in chronic hepatitis C patients who failed to interferon-alfa (IFNα)-based therapy.
METHODS: Seventy-five consecutive patients who failed to IFNα-based therapy were retreated with peginterferon plus ribavirin. Of these patients, 85% were infected by genotype 1. The primary endpoint was SVR.
RESULTS AND DISCUSSION: Of 75 non-responder (n = 54) or relapser patients (n = 21), 50 were previously treated with IFNα-monotherapy and 25 with IFNα plus ribavirin. Global SVR rate was 41.3%: for patients re-treated with IFNα the response was 48% whilst for those retreated with IFNα plus ribavirin, it was 28%. For previous non-responders the SVR rate was 37% and for relapsers it was 52.4%.
WHAT IS NEW AND CONCLUSION: Retreatment with peginterferon plus ribavirin is an effective option for some chronic hepatitis C non-responder or relapser patients. Higher SVR rate was achieved in relapsers and in those patients who received IFNα monotherapy previously.
M Trapero-Marugán; J Mendoza; J A Moreno Monteagudo; M Chaparro; L García-Buey; L González-Moreno; M J Borque; R Moreno-Otero
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-12-22
Journal Detail:
Title:  Journal of clinical pharmacy and therapeutics     Volume:  36     ISSN:  1365-2710     ISO Abbreviation:  J Clin Pharm Ther     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-10-25     Completed Date:  2012-02-13     Revised Date:  2012-09-10    
Medline Journal Info:
Nlm Unique ID:  8704308     Medline TA:  J Clin Pharm Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  695-703     Citation Subset:  IM    
Copyright Information:
© 2010 Blackwell Publishing Ltd.
Gastroenterology and Hepatology Service, Hospital Universitario de La Princesa, Autonomous University of Madrid, and Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain.
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MeSH Terms
Antiviral Agents / therapeutic use*
Drug Therapy, Combination
Hepatitis C, Chronic / drug therapy*,  virology
Interferon-alpha / therapeutic use*
Middle Aged
Polyethylene Glycols / therapeutic use*
Recombinant Proteins / therapeutic use
Ribavirin / therapeutic use*
Treatment Outcome
Reg. No./Substance:
0/Antiviral Agents; 0/Interferon-alpha; 0/Polyethylene Glycols; 0/Recombinant Proteins; 0/peginterferon alfa-2a; 0/peginterferon alfa-2b; 36791-04-5/Ribavirin

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