| Current advances in understanding of immunopathology of atherosclerosis. | |
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MedLine Citation:
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PMID: 21069384 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The importance of the involvement of the immune system in the development and progression of atherosclerosis was first suggested after the discovery of T cells in atherosclerotic lesions in 1990s. In order to be activated, T cell needs to be presented with an antigen but how this occurs in atherosclerosis has been unclear until recently. Current research has recognised dendritic cells as key initiators and regulators of immune processes in atherosclerosis. Accumulating evidence has revealed novel functions of several subsets of regulatory T cells, which have been shown to maintain immunological tolerance to self-antigens and to inhibit atherosclerosis development by suppressing the inflammatory response of effector T cells. Recent studies have also revealed the importance of natural killer T cells and their interaction with dendritic cells in atherogenesis. This review briefly summarises recent advances in the understanding of immune mechanisms in atherosclerosis and highlights the perspective of immunisation as an approach against this disease. |
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Authors:
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Colin-John Perrins; Yuri V Bobryshev |
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Publication Detail:
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Type: Journal Article Date: 2010-11-11 |
Journal Detail:
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Title: Virchows Archiv : an international journal of pathology Volume: 458 ISSN: 1432-2307 ISO Abbreviation: Virchows Arch. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9423843 Medline TA: Virchows Arch Country: Germany |
Other Details:
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Languages: eng Pagination: 117-23 Citation Subset: IM |
Affiliation:
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Faculty of Medicine, SOMS, University of New South Wales, Kensington, 2052, NSW, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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